Anti Cancer Medicines

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XTANDI (Enzalutamide 40mg) is a prescription medicine used to treat men with prostate cancer that: 
No longer responds to a hormone therapy or surgical treatment to lower testosterone or has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone. It is not known if XTANDI is safe and effective in females or children. XTANDI is an androgen receptor inhibitor. Androgens are a group of hormones that includes testosterone. Androgen receptor inhibitors interfere with the connection between androgens and androgen receptors. This can help slow cancer cell growth

Important Safety Information
What should I tell my doctor before taking XTANDI?
Tell your doctor about all your medical conditions, including if you:Have a history of seizures, brain injury, stroke, or brain tumors.Have a history of heart disease, have high blood pressure, or have abnormal amounts of fat or cholesterol in your blood (dyslipidemia). Are pregnant or plan to become pregnant. XTANDI can cause harm to your unborn baby and loss of pregnancy (miscarriage). Have a partner who is pregnant or may become pregnant.Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with XTANDI and for 3 months after the last dose. Males must use a condom during sex with a pregnant female. Are breast feeding or plan to breastfeed. It is not known if XTANDI passes into your breast milk. Take other medicines. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. These include prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not start or stop any medicine without talking to your doctor.

How should I take XTANDI?
Take XTANDI exactly as your doctor tells you. Take your prescribed dose once a day, at the same time each day. XTANDI can be taken with or without food. Swallow XTANDI capsules or tablets whole. Do not chew, dissolve, or open the capsules. Do not cut, crush or chew the tablets. Your doctor may change your dose if needed. Do not change or stop taking your prescribed dose of XTANDI without talking with your doctor first. If you are receiving gonadotropin-releasing hormone (GnRH) therapy, you should continue with this treatment while taking XTANDI unless you have had surgery to lower the amount of testosterone in your body (surgical castration). If you miss a dose of XTANDI: Take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI each day. If you take too much XTANDI: Call your doctor or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

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Enzalutamide and abiraterone acetate tablets are advanced oral therapies for metastatic castration-resistant prostate cancer. Enzalutamide blocks androgen receptor signaling, while abiraterone inhibits androgen synthesis. Together, they deliver a powerful dual-action approach, reducing tumor growth, delaying progression, and significantly improving survival and quality of life.

 

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Obnyx (Enzalutamide 40mg) is FDA approved generic oncology drug that is used to treat advanced forms of Prostate cancer, non-metastatic castration-resistant prostate cancer (nmCRPC).

A company statement declared that this is a drop of 70%, in comparison to the existing cost of therapy in India.

As per statement, the current MRP of Enzalutamide drug in India ranges from Rs. 70000 to Rs 80000 for a monthly therapy and can be a huge financial burden for the elderly patients as they need to continue the therapy for a long period of time. This price reduction will benefit many prostate cancer patients to adhere to the treatment.
The drug, named Enzalutamide, launched under the brand name Obnyx 40mg, will be available in soft gelatin capsules at a monthly treatment cost aprox of 357 US$.
In the U.S, Enzalutamide is sold under the Xtandi brand name.

Obnyx 40 mg capsule is usually taken as 4 capsules (4 * 40 mg = 160 mg), once a day at the same time.

According to the company statement, 1/9 Indian males have the threat of suffering from prostate cancer, which is almost 60% of males above the age of sixty-five.

Prostate cancer remains one of the major cancers in India. The drug assists the patients by decreasing the androgen hormones in their prostate glan. Enzalutamide is used to treat prostate cancer that has spread to other parts of the body in men and who have been helped by certain medical and surgical treatments that decrease testosterone levels.

Enzalutamide is a type of hormone therapy. It is a treatment for prostate cancer that has spread to other parts of the body (advanced prostate cancer)

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Indenza 40 mg (Enzalutamide) is an androgen receptor (AR) inhibitor indicated for patients suffering from prostate cancer types such as,

• Metastatic castration-resistant prostate cancer where other chemotherapy options (docetaxel) did not work. (cancer that lowers the growth of testosterone, a male hormone)
• Metastatic castration-sensitive prostate cancer where other hormonal therapy did not work (cancer that spreads to other parts of the body)

Peculiar properties of Indenza 40 mg (Enzalutamide) that helps in slowing down the growth of prostate cancer,

• Obstructs the communication tool of cancer cells (AR signaling i.e. binding with androgen receptor and interaction with DNA)
• Hinders the unwanted growth (Cell proliferation) of androgen (testosterone)
• Induces the act of self-destruction of cells (Apoptosis)
• Reduces the risk of progression and death
• Postpones the requirement of chemotherapy

Administration of Indenza 40 mg (Enzalutamide):

Indenza 40 mg (Enzalutamide) is given orally in a 160 mg dosage (4×40 mg) once in 24 hours with or without food. If patients experience any sort of side-effects, the dosage can be modified and reduced to 120 mg (3×40 mg) or 80 mg (2×40 mg).

Once swallowed, enzalutamide is readily soluble (bio-available) in the body within 3 hours. It is metabolized in the liver and then distributed throughout the region of cancer with a high binding affinity (97%) to cancer cells. Once enzalutamide completes its activities, more than 50% of the dose is expelled from the body in between 3 to 11 days.

When should Indenza 40 mg (Enzalutamide) be avoided or used cautiously?

• If patients have a history of or experience sudden unwarranted changes in behaviour caused due to disturbances in the brain (Seizures)
• If patients are confirmed with symptoms like headache, impaired vision and low blood pressure (Posterior reversible encephalopathy syndrome)
• If patients are seen with kidney diseases (severe renal impairment and end-stage renal disease)
• If patients show signs of severe disease of the liver
• If patients are seen with a relative risk of heart diseases
• If patients are allergic to dosage and show symptoms like tongue, lip, or pharyngeal swelling (edema)
• If patients are intolerant to lactose

Side-effects of Indenza 40 mg (Enzalutamide):
Most common side-effects:

• Tiredness (Fatigue)
• Pain in the back, muscles, bones and joints
• Diarrhea
• Weakness in the muscles
• Dizziness
• Swelling (edema) in the hands and legs
• Severe headache
• Cold-like symptoms
• Anxiety or stress

Other side-effects:

• Discoloured urine in pink or red colour (Hematuria)
• Rashes on skin
• Trouble in falling asleep (insomnia)
• Trouble in breathing (pneumonia)
• Weakness in the legs
• Pain in the lower back
• High blood pressure (Hypertension)
• Burning or numbness of skin (paresthesia)
• Excitement or confusion
• Loss of memory
• Nightmares

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Capmide 40mg Capsule is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Capmide 40mg Capsule should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, hot flashes, weakness and high blood pressure is very common side effect of this medicine. Other than this, yellowing of skin, loss of appetite, shortness of breath, abdominal pain, dark urine, and skin rashes might be observed as side effects. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

Benefits Of Capmide Capsule:
In Prostate cancerProstate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Capmide 40mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side Effects Of Capmide Capsule:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Capmide:

• Headache
• Hot flashes
• Weakness
• High blood pressure
• Fatigue

How To Use Capmide Capsule:
Take this medicine in the dose and duration as advised by your doctor. Capmide 40mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Capmide Capsule works:
Capmide 40mg Capsule is an antiandrogens. It works by blocking the effect of the natural male hormones on the growth of prostate cells.

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Enzamide (Enzalutamide 40mg) Tablet is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

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Azel (Enzalutamide 40mg) Capsule is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Azel 40mg Capsule should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, hot flashes, weakness and high blood pressure is very common side effect of this medicine. Other than this, yellowing of skin, loss of appetite, shortness of breath, abdominal pain, dark urine, and skin rashes might be observed as side effects. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

Benefits Of Azel Capsule:
In Prostate cancer Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Azel 40mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side Effects Of Azel Capsule:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

How To Use Azel Capsule:
Take this medicine in the dose and duration as advised by your doctor. Azel 40mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Azel Capsule Works:
Azel 40mg Capsule is an antiandrogens. It works by blocking the effect of the natural male hormones on the growth of prostate cells.

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Nintedanib, sold under the brand names BDR and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.

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Azacitidine (trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative, decitabine are used in the treatment of myelodysplastic syndrome. Both drugs were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.

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Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.  Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.  Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.  Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. You must avoid driving if you experience dizziness or blurred vision during treatment. 

Uses Of Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet: 
Blood cancer (Chronic myeloid leukaemia) 

Benefits OF Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet:
In Blood cancer (Chronic myeloid leukaemia) Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side Effects Of Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Dasatinib (20 Mg, 50 Mg, 70 Mg) Abdominal pain Anemia (low number of red blood cells) Breathing problems Fatigue Fever Headache Infection Low blood platelets Musculoskeletal (bone, muscle or joint) pain Nausea Rash Vomiting.

How to use Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet: 
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet may be taken with or without food, but it is better to take it at a fixed time. 

How Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet Works: 
Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
 
Safety Advice:
It is not known whether it is safe to consume alcohol with Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet. 

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Cyendiv (Nintedanib  100mg , 150mg ) is a prescription medicine used:

• To treat people with a lung disease called idiopathic pulmonary fibrosis (IPF).
• To treat people with a chronic (long lasting) interstitial lung disease in which lung fibrosis continues to worsen (progress).
• To slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD) (also known as scleroderma-associated ILD).
• It is not known if Cyendiv is safe and effective in children.

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Zyceva (Erlotinib 150mg) Tablet is used in the treatment of non-small cell lung cancer and pancreatic cancer.

Zyceva 150mg Tablet should be taken on an empty stomach or should be taken one hour before or 2 hour after meal.  You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your needs and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, fatigue, rash, and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. It makes you sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out. In case you develop ulceration in mouth, changes in your vision, or breathing difficulties than it is better to inform the doctor. Your doctor may advise for regular monitoring of liver function while you are taking this medicine.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.  It is advised to quit smoking while taking this medicine as it can affect the working of the medicine. If you have to take an antacid or any other medicine, take it at a gap of at least 2 hours after taking the cancer medicine.

Uses Of Zyceva Tablet:

• Non-small cell lung cancer
• Pancreatic cancer

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Erlonat (Erlotinib 150mg) Tablet is used in the treatment of non-small cell lung cancer and pancreatic cancer.
Erlonat 150 Tablet should be taken on an empty stomach or should be taken one hour before or 2 hour after meal.  You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your needs and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, fatigue, rash, and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. It makes you sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out. In case you develop ulceration in mouth, changes in your vision, or breathing difficulties than it is better to inform the doctor. Your doctor may advise for regular monitoring of liver function while you are taking this medicine.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.  It is advised to quit smoking while taking this medicine as it can affect the working of the medicine. If you have to take an antacid or any other medicine, take it at a gap of at least 2 hours after taking the cancer medicine.

Uses Of Erlonat Tablet:
Non-small cell lung cancer, Pancreatic cancer.

Benefits Of Erlonat Tablet:
In Non-small cell lung cancerNon-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers. Erlonat 150 Tablet helps treat non-small cell lung cancer and may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

More Side Of Erlonat Tablet:

• Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about themCommon side effects of ErlonatAbdominal painBone painBreathlessnessConstipationCoughDiarrheaFatigueFeverInfectionMuscle painNauseaRashStomatitis (Inflammation of the mouth)Vomiting Weight loss.

How To Use Erlonat Tablet:

• Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Erlonat 150 Tablet is to be taken empty stomach.

How Erlonat Tablet Works:

• Erlonat 150 Tablet is an anti-cancer medication. Epidermal growth factor receptors (EGFR) are expressed on the lung cancer cell surfaces that modulate their growth. This medicine works by binding the chemical messenger, EGFR, hence, inhibits the cancer signaling pathways mediated by EGFR. This is how it restricts further growth of the cancer cells.

Safety Advice:

• It is not known whether it is safe to consume alcohol with Erlonat 150 Tablet. 
• Erlonat 150 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situation.

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Herlapsa (Lapatinib 250mg) Tablet is used in the treatment of breast cancer. It shows its working by stopping or slowing down the growth of cancer cells. It is either used alone or in combination with some other medicine to cure advanced stage of breast cancer.

Herlapsa Tablet should be taken on an empty stomach or should be taken one hour before or 2 hour after meal.  You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your need and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, headache, back pain, and breathing difficulty. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. You may be asked for regular monitoring of blood pressure while taking this medicine, inform your doctor if you notice severe headache, confusion, problems with your eyesight, nausea or vomiting. It might cause serious skin reaction, inform your doctor if you notice rash, red skin, blistering of the lips, eyes or mouth, skin peeling. You may be also checked for liver functioning before and after the treatment.

Before taking this medicine, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses Of Herlapsa Tablet:
Breast cancer

Side Effecta Of Herlapsa Tablet: 
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Herlapsa:

• Abdominal pain
• Back pain
• Breathing problems
• Constipation
• Cough
• Diarrhea
• Fatigue
• Headache
• Hot flashes
• Increased bilirubin in the blood
• Insomnia (difficulty in sleeping)
• Joint pain
• Liver damage
• Loss of appetite
• Mucosal inflammation
• Nausea
• Pain in extremity
• Rash
• Stomatitis (Inflammation of the mouth)
• Vomiting
• Weakness
• Weight gain

How To Use Herlapsa Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Herlapsa Tablet is to be taken empty stomach.

How Herlapsa Tablet Works:
Herlapsa Tablet is an anti-cancer medication. This works against the HER2 (human epidermal growth factor receptor protein) receptors and EGFRs (epidermal growth factor receptor) which is responsible for the over-proliferation of cells. This is how it inhibits the growth of cancerous cells causing downstream signaling pathways.

Safety Advice:

• It is not known whether it is safe to consume alcohol with Herlapsa Tablet. 
• Herlapsa Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. 
• Herlapsa Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

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Combinib (Lapatinib  250 mg) in combination with capecitabine, is indicated for the treatments of the patients with advanced or metastatic breast cancer whose tumor overexpress HER2+/neu (ErbB2) and who have received prior therapy including trastuzumab.

In combination with letrozole for the treatment of postmenopausal women with hormone receptor positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated.

Lapatinib in combination with trastuzumab, indicated for the treatment of the patients with hormone receptor-negative metastatic breast cancer whose tumours overexpress HER2/neu(ErbB2) and who have progressed on prior trastuzumab therapy in combination with chemotherapy in the metastatic setting.

Dose & Method of Administration:
Lapatinib treatment should only be initiated by a physician experienced in the administration of anti-cancer medicinal products.

HER2(ErbB2) overexpressing tumours are defined by IHC3+, or IHC2+ with gene amplification or gene amplification alone. HER2 status should be determined using accurate and validated methods.

Posology
Lapatinib/Capecitabine Combination Posology

The recommended dose of Lapatinib is 1250 mg (i.e. five tablets) once daily continuously.

The recommended dose of capecitabine is 2000 mg/m2/day taken in 2 dose 12 hours apart on days 1-14 in a 21 day cycle. Capecitabine should be taken with food or within 30 minutes after food. Please refer to the full prescribing information of capecitabine.

Lapatinib/trastuzumab Combination Posology:
The recommended dose of Lapatinib is 1250mg (i.e. four tablets) once daily continuously.

The recommended dose of trastuzumab is 4 mg/kg administered as an intravenous (IV) loading dose, followed by 2 mg/kg IV weekly. Please refer to the full prescribing information of trastuzumab.

Lapatinib/Aromatase Inhibitor Combination Posology:
The recommended dose of Lapatinib is 1500mg (i.e. six tablets) once daily continuously.

Please refer to the full prescribing information of the co-administered aromatase inhibitor for dosing details.

Dose Delay and Dose Reduction

Cardiac Events:
Lapatinib should be discontinued in patients with symptoms associated with decreased left ventricular ejection fraction (LVEF)that are National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) grade 3 or greater or if there LVEF drops below the institutions lower limit of normal. Lapatinib may be restarted at a reduce dose (750 mg/day when administered with trastuzumab,1000 mg/day when administered with capecitabine or 1250 mg/day when administered with an aromatase inhibitor) after a minimum of 2 weeks and if the LVEF recovers to the normal and the patient is asymptomatic.

Interstitial Lung Disease/Pneumonitis:
Lapatinib should be discontinued in patients who experience pulmonary symptoms which are NCICTACAE grade 3 or greater.

Diarrhoea:
Lapatinib should be interrupted in patients with diarrhoea which is NCI CTCAE grade 3 or grade 1 or with 2 complicating features (moderate to serve abdominal cramping, nausea or vomiting greater than or equal to NCI CTCAE grade 2, decreased performance status, fever, sepsis, neutropenia, frank bleeding or dehydration). Lapatinib may be reintroduced at a lower dose (reduce from 1000mg/day to 750 mg/day, from 1250 mg/day to 1000mg/day or from 1500 mg/day to 1250 mg/day) when diarrhoea resolves to grade 1 or less. Lapatinib dosing should be permanently discontinued in patients with diarrhoea which is NIC CTCAE grade4.

Other Toxicities:
Discontinuation or interruption of dosing with Lapatinib may be considered when a patient develop toxicity greater than or equal to grade 2 on the NCI CTCAE.

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Evertor (Everolimus 10mg) Tablet is used for the prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ. It is also used in combination with other medicines to treat cancers of breast, pancreas, lungs, and kidney. Evertor 10mg Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body. The common side effects of this medicine are weakness, sinus inflammation, infection, fever, cough, etc. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions (rash, shortness of breath, coughing, swelling, etc.). Always seek medical advice if you have increased thirst or increased frequency of urination, suffer from shortness of breath, cough or fever, or need to receive any vaccination after taking this medication. Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. It may affect male or female fertility, so consult the doctor if you are planning to have a child.

Uses Of Evertor Tablet:
Prevention of organ rejection in transplant patients Treatment of Breast cancer Treatment of Pancreatic cancer Treatment of Lung cancer Treatment of Kidney cancer.

Benefits Of Evertor Tablet:
In Prevention of organ rejection in transplant patients Evertor 10mg Tablet is used with other medications to prevent organ transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving any organ transplants, like kidney, liver, heart etc. This medicine reduces the activity of a person's own immune system and prevents any such rejection. In Treatment of Breast cancer Evertor 10mg Tablet is used to treat breast cancer in postmenopausal women when other medicines have failed to show significant improvement. It helps to stop cancer growth and further spread and relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. Take is as advised to get maximum relief. In Treatment of Pancreatic cancer Pancreas are very essential for digestion of whatever you eat and also for metabolism of blood sugar levels as they produce the body’s natural insulin. This medicine will help to control pancreatic cancer, and will relieve the symptoms such as, lack of appetite or unexplained weight loss. Evertor 10mg Tablet helps to stop the action of those chemicals that aid in pancreatic cancer growth and spread. It will help you live a longer and healthier life. In Treatment of Lung cancer Evertor 10mg Tablet reduces the blood supply to the cancer cells and stops its growth. But, as it reduces the immunity, avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to. Take a healthy diet and keep taking the medicine as prescribed to get the full benefits. In Treatment of Kidney cancer Evertor 10mg Tablet is used to treat kidney cancer when other medicines have failed to work. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover. Take it as prescribed to get the maximum benefit.

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Nintib (Nintedanib  100mg , 150mg) is a prescription medicine used:to treat people with a lung disease called idiopathic pulmonary fibrosis (IPF).to treat people with a chronic (long lasting) interstitial lung disease in which lung fibrosis continues to worsen (progress).to slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD) (also known as scleroderma-associated ILD).It is not known if Nintib is safe and effective in children.What are the possible side effects of Nintib?Nintib may cause serious side effects, including:See “What is the most important information I should know about Nintib?”liver problems. Call your doctor right away if you have unexplained symptoms such as yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea colored) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal, feeling tired, or loss of appetite. Your doctor will do blood tests to check how well your liver is working before starting and during your treatment with Nintib.diarrhea, nausea, and vomiting. While you are taking Nintib, your doctor may recommend that you drink fluids or take medicine to treat these side effects. Tell your doctor if you have diarrhea, nausea, or vomiting or if these symptoms do not go away or become worse. Tell your doctor if you are taking over-the-counter laxatives, stool softeners, and other medicines or dietary supplements that can cause diarrhea.heart attack. Tell your doctor right away if you have symptoms of a heart problem. These symptoms may include chest pain or pressure, pain in your arms, back, neck or jaw, or shortness of breath.stroke. Tell your doctor right away if you have symptoms of a stroke. These symptoms may include numbness or weakness on 1 side of your body, trouble talking, headache, or dizziness.bleeding problems. Nintib may increase your chances of having bleeding problems. Tell your doctor if you have unusual bleeding, bruising, or wounds that do not heal. Tell your doctor if you are taking a blood thinner, including prescription blood thinners and over-the-counter aspirin.tear in your stomach or intestinal wall (perforation). Nintib may increase your chances of having a tear in your stomach or intestinal wall. Tell your doctor if you have pain or swelling in your stomach area.The most common side effects of Nintib are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure.

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Dasanat (Dasatinib 50mg) Tablet is used for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), a type of blood cancer that occurs due to a chromosome abnormality. It is also used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), a type of white blood cell cancer where the bone marrow produces cancerous and immature lymphoblasts in large quantities. This medicine is not recommended for patients below 1 year of age.Side effectsMajor & minor side effects for Dasanat 50 TabletBody aches or PainBurning, numbness, tingling in the arms and feetChest painChillsCoughDizzinessHeadacheWeight gainFeverIrritation of throatUlcers or white spots in the mouthNauseaIrregular breathingIncreased sweatingUses of Dasanat 50 TabletWhat is it prescribed for?Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)This medicine is used for the treatment of advanced and newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase in patients who have acquired resistance or intolerance to prior therapy.Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)This medicine is used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), a type of white blood cell cancer where the bone marrow produces cancerous lymphocytes. It is used in patients who have acquired resistance or intolerance to prior therapy. WarningsWarnings for special populationPregnancyThis medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.Breast-feedingThis medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.General warningsGastrointestinal disordersThis medicine should be used with caution in patients having a pre-existing disorder of the stomach or the intestine due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be necessary based on the clinical condition.Driving or Operating machineryUse of this medicine may cause dizziness and blurring of vision. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.Bonemarrow suppressionThis medicine should be used with caution in patients having conditions like thrombocytopenia, agranulocytosis, anemia, or bone marrow suppression due to the increased risk of worsening of the patient's condition. A complete blood count should be performed before initiating treatment with this medicine. Close monitoring of blood counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.Internal bleeding or hemorrhageThis medicine should be used with caution due to the increased risk of internal bleeding or hemorrhages. Any symptoms such as unusual bleeding or bruising, black or tarry stools, vomiting up blood, etc. should be reported to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.Risk of infectionsUse of this medicine may weaken the immune system and may make you more vulnerable to infections. It is advised that you avoid coming in contact with people suffering from an infection while taking this medicine.

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Pazopanib, sold under the brand name Votrient, is an anti-cancer medication marketed worldwide by Novartis. It is a potent and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis. It has been approved for renal cell carcinoma and soft tissue sarcoma by numerous regulatory administrations worldwide

It is approved by numerous regulatory administrations worldwide, including the US Food and Drug Administration (FDA) (19 October 2009), the European Union's European Medicines Agency (EMA) (14 June 2010), the United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) (14 June 2010) and Australia's Therapeutic Goods Administration (TGA) (30 June 2010), for use as a treatment for advanced/metastatic renal cell carcinoma and advanced soft tissue sarcomas.

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Sprycel(Dasatinib 20mg 50mg 70mg ) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.Sprycel 20mg 50mg 70mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. You must avoid driving if you experience dizziness or blurred vision during treatment.

Uses Of Sprycel Tablet:
Blood cancer (Chronic myeloid leukaemia).

Benefits Of Sprycel Tablet:
In Blood cancer (Chronic myeloid leukaemia)Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Sprycel 20mg 50mg 70mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side Effects Of Sprycel Tablet:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Common side effects of Sprycel Abdominal pain, Anemia (low number of red blood cells)Breathing problems, Fatigue, Fever, Headache, Infection, Low blood platelets, Musculoskeletal (bone, muscle or joint) pain, Nausea, Rash, Vomiting.

How To Use Sprycel Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sprycel 20mg 50mg 70mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Sprycel Tablet Works:
Sprycel 20mg 50mg 70mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety Advice:

• It is not known whether it is safe to consume alcohol with Sprycel 20mg 50mg 70mg Tablet. 
• Sprycel 20mg 50mg 70mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. 
• Sprycel 20mg 50mg 70mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

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Nilotinib (150mg,200mg) capsules is a prescription medicine used to treat: Adults with newly diagnosed Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phaseAdults with Ph+ CML in chronic phase.

Important Safety Information: 
QTc Prolongation and Sudden Death: Nilotinib can cause QTc prolongation, a possibly life-threatening heart problem. QTc prolongation causes an irregular heartbeat, which may lead to sudden death. Call your doctor right away if you feel lightheaded, faint, or have an irregular heartbeat while taking Nilotinib . These can be symptoms of QTc prolongation.
Your doctor should check your heart with a test called an electrocardiogram (ECG)Do not take Nilotinib if you have long QTc syndrome or low levels of potassium or magnesium in your bloodNilotinib can interact with many medicines and supplements. This may increase your chances for serious and life-threatening side effects. Do not take any other medicine while taking Nilotinib unless your doctor tells you it is okay to do soFood and grapefruit products increase the amount of Nilotinib in your body. This may increase your chances for serious and life-threatening side effects. Take Nilotinib on an empty stomachAvoid eating food for at least 2 hours before the dose is taken, and avoid eating food for at least 1 hour after the dose is takenAvoid grapefruit, grapefruit juice, and any supplement containing grapefruit extract while taking Nilotinib Nilotinib can cause serious side effects that can even lead to death. During treatment with Nilotinib your doctor will do tests to check for side effects. These tests will check your heart, blood cells (white blood cells, red blood cells, and platelets), electrolytes (potassium, magnesium), cholesterol, blood sugar, and pancreas and liver function. Your doctor may have you stop Nilotinib for some time or lower your dose if you have side effects. You should follow your doctor’s instructions. Serious side effects include:

Low Blood Counts: Low blood counts are common with Nilotinib but can also be severe. Your doctor will check your blood counts regularly during treatment with Nilotinib . Call your doctor right away if you have symptoms of low blood counts including:Fever, chills, or other signs of infectionUnexplained bleeding or bruisingShortness of breathUnexplained weakness Decreased Blood Flow to the Legs, Heart, or Brain: People who have recently been diagnosed with Ph+ CML and take Nilotinib may develop decreased blood flow to the legs, heart, or brain. Get medical help right away if you suddenly develop any of the following symptoms:Chest pain or discomfortNumbness or weaknessProblems walking or speakingLeg pain or your leg feels cold Change in the skin color of your leg Pancreas Inflammation (Pancreatitis): Call your doctor if you have symptoms including sudden stomach area pain with nausea and vomiting

Liver Problems: Nilotinib can increase your risk of liver problems. People who have had liver problems in the past may be at risk for getting liver problems with Nilotinib . Call your doctor, or get medical help right away if you develop any symptoms of liver problems including stomach area (abdominal) pain, yellow skin/eyes, and dark-colored urine

Tumor Lysis Syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. Your doctor may do blood tests to check you for TLS. TLS can cause you to have kidney failure (with the need for dialysis treatment) and/or an abnormal heartbeat

Bleeding Problems: Serious bleeding problems and death have happened during treatment with Nilotinib . Call your doctor right away if you develop signs and symptoms of bleeding such as uncontrolled bleeding, changes in eyesight, unconsciousness, sudden headache, or sudden confusion about your surroundings.

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DYRONIB (Dasatinib 70mg ) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.
DYRONIB 70mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. 

Uses Of Sprycel Tablet:
Blood cancer (Chronic myeloid leukaemia).

Benefits Of Sprycel Tablet:
In Blood cancer (Chronic myeloid leukaemia)Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. DYRONIB 70mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side Effects Of Sprycel Tablet:
TMost side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Sprycel Abdominal pain Anemia (low number of red blood cells)Breathing problems, Fatigue, Fever,Headache, Infection, Low blood platelets, Musculoskeletal (bone, muscle or joint) pain Nausea Rash Vomiting.

How To Use Sprycel Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. DYRONIB 70mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Sprycel Tablet Works:
DYRONIB 70mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety Advice:

• It is not known whether it is safe to consume alcohol with DYRONIB 70mg Tablet.
• DYRONIB 70mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. 
• DYRONIB 70mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
• DYRONIB 70mg Tablet may cause side effects which could affect your ability to drive.Take special care when driving in case you experience side effects such as dizziness and blurred vision with DYRONIB 70mg Tablet

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Lenalid (Lenalidomide 5mg ,10mg,  25mg)is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). Lenalid should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if Lenalid is safe and effective in children.

What is the most important information I should know about Lenalid?
Before you begin taking Lenalid, you must read and agree to all of the instructions in the Lenalid REMS program. Before prescribing Lenalid, your healthcare provider will explain the Lenalid REMS program to you and have you sign the Patient-Physician Agreement Form.

Lenalid may cause serious side effects, including:
Possible birth defects (deformed babies) or death of an unborn baby. Females who are pregnant or who plan to become pregnant must not take Lenalid.

Lenalid is similar to the medicine thalidomide which is known to cause severe life-threatening birth defects. Lenalid has not been tested in pregnant females. Lenalid has harmed unborn animals in animal testing.Females must not get pregnant:For at least 4 weeks before starting LenalidWhile taking LenalidDuring any breaks (interruptions) in your treatment with LenalidFor at least 4 weeks after stopping LenalidFemales who can become pregnant:
Must have pregnancy tests weekly for 4 weeks, then every 4 weeks if your menstrual cycle is regular, or every 2 weeks if your menstrual cycle is irregular.If you miss your period or have unusual bleeding, you will need to have a pregnancy test and receive counseling. Must agree to use 2 different forms of effective birth control at the same time, for at least 4 weeks before, while taking, during any breaks (interruptions) in your treatment, and for at least 4 weeks after stopping Lenalid. Talk with your healthcare provider to find out about options for effective forms of birth control that you may use to prevent pregnancy before, during, and after treatment with Lenalid. If you had unprotected sex or if you think your birth control has failed, stop taking Lenalid immediately and call your healthcare provider right away. If you become pregnant while taking Lenalid, stop taking it right away and call your healthcare provider.

Approx. Rs 5,000 / BottleGet Latest Price

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Rucaparib 200 Mg tablets are a prescription medicine used in adults for:the maintenance treatment of ovarian cancer, fallopian tube cancer, or primary peritoneal cancer whose cancer has come back and who are in response (complete or partial response) to a platinum-based chemotherapythe treatment of ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have certain “BRCA” gene mutations, either inherited (germline) or acquired (somatic), and who have been treated with 2 or more chemotherapy medicines for their cancer. Your healthcare provider will perform a test to make sure Rucaparib 200 Mg is right for you.the treatment of castration-resistant prostate cancer (prostate cancer that no longer responds to medical or surgical treatment that lowers testosterone):that has spread to other parts of the body, andhas a certain type of inherited (germline) or acquired (somatic) abnormal BRCA gene, and you have been treated with certain medicines for your cancer.Rucaparib 200 Mg was approved based on response rate and how long patients’ responses lasted. There are ongoing studies to confirm the clinical benefit of Rucaparib 200 Mg. Your healthcare provider will perform a test to make sure Rucaparib 200 Mg is right for you.It is not known if Rucaparib 200 Mg is safe and effective in children.SELECT IMPORTANT SAFETY INFORMATIONWhat Warnings should I know about Rucaparib 200 Mg?Rucaparib 200 Mg tablets may cause serious side effects including bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of cancer of the blood called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with Rucaparib 200 Mg, although MDS or AML was not observed in men with prostate cancer during the clinical study. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with Rucaparib 200 Mg. You should not use Rucaparib 200 Mg if:You are pregnant or plan to become pregnant. Rucaparib 200 Mg can harm your unborn baby and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Rucaparib 200 Mg.If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Rucaparib 200 Mg.Females who are able to become pregnant should use effective birth control during treatment and for at least 6 months after receiving the last dose of Rucaparib 200 Mg.Talk to your healthcare provider about birth control methods that may be right for you.Tell your healthcare provider right away if you become pregnant.You are breastfeeding or plan to breastfeed. It is not known if Rucaparib 200 Mg passes into breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose of Rucaparib 200 Mg. Talk to your healthcare provider about the best way to feed your baby during this time.If you are a male with a female partner who is pregnant or able to become pregnant. Effective birth control should be used during treatment and for 3 months after the last dose of Rucaparib 200 Mg. Do not donate sperm during use and for 3 months after the last dose of Rucaparib 200 Mg.What other important information should I know about Rucaparib 200 Mg?Your healthcare provider will do blood tests before, and every month during treatment with Rucaparib 200 Mg to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts for a long time. Your healthcare provider may stop treatment with Rucaparib 200 Mg until your blood cell counts improve. Avoid spending time in sunlight while on Rucaparib 200 Mg since your skin may become more sensitive to the sun and may sunburn more easily.

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DASATRUE(Dasatinib 70 mg ) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.
DASATRUE 70 mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. You must avoid driving if you experience dizziness or blurred vision during treatment.

Uses Of DASATRUE Tablet:
Blood cancer (Chronic myeloid leukaemia)

Benefits Of DASATRUE Tablet:
In Blood cancer (Chronic myeloid leukaemia)Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. DASATRUE 70 mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side Effects Of DASATRUE Tablet:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Dasature Abdominal pain Anemia (low number of red blood cells)Breathing problemsFatigue, Fever, Headache, Infection, Low blood platelets, Musculoskeletal (bone, muscle or joint) pain Nausea, Rash, Vomiting.

How To Use DASATRUE Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. DASATRUE 70 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How DASATRUE Tablet Works:
DASATRUE 70 mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety Advice:

• It is not known whether it is safe to consume alcohol with DASATRUE 70 mg Tablet. 
• DASATRUE 70 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. 
• DASATRUE 70 mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
• DASATRUE 70 mg Tablet may cause side effects which could affect your ability to drive.

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Erlocip (Erlotinib 150mg) Tablet is used in the treatment of non-small cell lung cancer and pancreatic cancer.

Erlocip 150 Tablet should be taken on an empty stomach or should be taken one hour before or 2 hour after meal.  You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your needs and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, fatigue, rash, and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. It makes you sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out. In case you develop ulceration in mouth, changes in your vision, or breathing difficulties than it is better to inform the doctor. 

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.  It is advised to quit smoking while taking this medicine as it can affect the working of the medicine. If you have to take an antacid or any other medicine, take it at a gap of at least 2 hours after taking the cancer medicine.

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DASASHEEL (Dasatinib 20mg 50mg 70mg ) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.

DASASHEEL 20mg 50mg 70mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. You must avoid driving if you experience dizziness or blurred vision during treatment.

Uses Of Dasasheel Tablet:
Blood cancer (Chronic myeloid leukaemia)

Benefits Of Dasasheel Tablet:

• In Blood cancer (Chronic myeloid leukaemia)
• Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. DASASHEEL 20mg 50mg 70mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

How To Use Dasasheel Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. DASASHEEL 20mg 50mg 70mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Dasasheel Tablet Works:
DASASHEEL 20mg 50mg 70mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

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• Zoledronic Acid Injection IP bone is used to treat thinning and weakening of the bone (osteoporosis) and to prevent bone complications, e.g. fractures, in adult patients due to spread of cancer from other organs to .
• Zoledronic Acid Injection IP belongs to a class of drugs known as bisphosphonates. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.
• For Intravenous Infusion Sterile, Lyophilized

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We are offering Erlotinib Tablets IP which is a Kinase inhibitor which is primarily used to treat cell lung cancer, or pancreatic cancer when combined with a certain other medications. It works by inhibiting growth to adjacent tissues in the body so that the cancerous cells slow down, allowing the patient a better environment to recover and fight cancer naturally.

Dosage and Administration:

• Typically, an adult patient will be instructed to take between 100mg and 150mg of Erlonat (Erlotinib), at least 1 hour before any meals or snacks and 2 hours after. Unless otherwise instructed, you should always swallow each tablet whole without chewing, crushing, splitting, or dissolving the tablet in liquid. Wash tablets down with full glass of water.

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Dasakast (dasatinib 70mg) is an oral drug indicated for patients suffering from blood cancer in both adults and children. Specifically, dasakast 50 mg (dasatinib) is used in adults with Chronic myeloid leukemia (CML) in a long-lasting (chronic) phase of the disease. Dasatinib belongs to the class of medicine known as kinase inhibitors that works its action by:

• Firstly, blocking the activities of abnormal protein
• Secondly, hindering the multiplication of cancer cells (cell-proliferation)
• Lastly, reducing blood flow to the cancer cells (angiogenesis)

Dasatinib, with the above actions, finally disrupts the spread of CML cancer cells.

Administration of Dasakast 50 mg (Dasatinib):
Dasakast (dasatinib) is given in the form of 100 mg dose (2×50 mg tablets) once daily. However, if the condition of patients does not improve, the dose is escalated to 140 mg (2×100 mg tablets) once daily. It can be taken with or without food in the morning or evening. Once swallowed, dasatinib is completely absorbed (bio-available) in 6 hours and is distributed throughout the region of cancer. It is metabolized in liver by different types of proteins and subsequently after completing its action, more than 50% of dasatinib is expelled from the body within 3 to 5 hours.

 

When should Dasakast 50 mg (Dasatinib) be avoided or used cautiously:

• In patients having a severe risk of bleeding (hemorrhage), carry out blood tests regularly
• If patients carry an infection (fever) caused due to decrease in blood cells (myelosuppression)
• If patients have symptoms like swelling, dry cough, shortness of breath or weight gain leading to the loss of fluids (fluid retention) in body
• If patients are suffering from shortness of breath, tiredness, or hypoxia) causing increase in blood pressure (Hypertension)
• If patients had a history of heart problems (heart attack or heart failure)
• If patients are seen with nausea, vomiting, weakness or cramps in the muscles, a condition where the cancerous cells are overkilled spraying their contents in the blood (tumor lysis syndrome), could be present
• If patients are pregnant or planning to get pregnant
• If patients face complications in stomach or intestine

 

Most common side-effects of Dasakast 50 mg (Dasatinib):

• Diarrhoea
• Headache
• Pain in the muscles (myalgia)
• Rashes on the skin
• Nausea
• Tiredness
• Shortness of breath
• Excessive bleeding

 

The uncommon ones are:

• Pain in the stomach and intestinal regions
• Vomiting
• Constipation
• Weight gain
• Chills
• Inconsistent heartbeat (Arrythmia)
• Fever with other signs of infection (Febrile neutropenia)
• Decrease in RBCs i.e. Hemoglobin (anemia)
• Decrease in platelets (thrombocytopenia)

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REVLIMID (lenalidomide 5mg 10mg 25mg) is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). REVLIMID should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if REVLIMID is safe and effective in children.What is the most important information I should know about REVLIMID?Before you begin taking REVLIMID, you must read and agree to all of the instructions in the REVLIMID REMS® program. Before prescribing REVLIMID, your healthcare provider will explain the REVLIMID REMS program to you and have you sign the Patient-Physician Agreement Form.
REVLIMID may cause serious side effects, including:
Possible birth defects (deformed babies) or death of an unborn baby. Females who are pregnant or who plan to become pregnant must not take REVLIMID.
REVLIMID is similar to the medicine thalidomide which is known to cause severe life-threatening birth defects. REVLIMID has not been tested in pregnant females. REVLIMID has harmed unborn animals in animal testing.Females must not get pregnant:For at least 4 weeks before starting REVLIMIDWhile taking REVLIMIDDuring any breaks (interruptions) in your treatment with REVLIMIDFor at least 4 weeks after stopping REVLIMIDFemales who can become pregnant:
Must have pregnancy tests weekly for 4 weeks, then every 4 weeks if your menstrual cycle is regular, or every 2 weeks if your menstrual cycle is irregular.If you miss your period or have unusual bleeding, you will need to have a pregnancy test and receive counseling.Must agree to use 2 different forms of effective birth control at the same time, for at least 4 weeks before, while taking, during any breaks (interruptions) in your treatment, and for at least 4 weeks after stopping REVLIMID.Talk with your healthcare provider to find out about options for effective forms of birth control that you may use to prevent pregnancy before, during, and after treatment with REVLIMID.If you had unprotected sex or if you think your birth control has failed, stop taking REVLIMID immediately and call your healthcare provider right away.If you become pregnant while taking REVLIMID, stop taking it right away and call your healthcare provider. If your healthcare provider is not available, you can call Celgene Customer Care Center at 1-888-423-5436. Healthcare providers and patients should report all cases of pregnancy to:
FDA MedWatch at 1-800-FDA-1088, andCelgene Corporation, a Bristol Myers Squibb company, at 1-888-423-5436.There is a pregnancy exposure registry that monitors the outcomes of females who take REVLIMID during pregnancy, or if their male partner takes REVLIMID and they are exposed during pregnancy. You can enroll in this registry by calling Celgene Corporation, a Bristol Myers Squibb company, at the phone number listed above.
REVLIMID can pass into human semen:
Males, including those who have had a vasectomy, must always use a latex or synthetic condom during any sexual contact with a pregnant female or a female that can become pregnant while taking REVLIMID, during any breaks (interruptions) in your treatment with REVLIMID, and for up to 4 weeks after stopping REVLIMID.Do not have unprotected sexual contact with a female who is or could become pregnant. Tell your healthcare provider if you do have unprotected sexual contact with a female who is or could become pregnant.Do not donate sperm while taking REVLIMID, during any breaks (interruptions) in your treatment, and for 4 weeks after stopping REVLIMID. If a female becomes pregnant with your sperm, the baby may be exposed to REVLIMID and may be born with birth defects

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Veenat (Imatinib mesylate 400mg) Tablet belongs to the class of medicines known as tyrosine kinase inhibitors. It is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumor. Veenat 400 Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. 

Uses Of Veenat Tablet: 
Blood cancer (Chronic myeloid leukaemia) Blood cancer (Acute lymphocytic leukemia) Gastrointestinal stromal tumour. 

Benefits Of Veenat Tablet: 
In Blood cancer (Chronic myeloid leukaemia) Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Veenat 400 Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated. In Blood cancer (Acute lymphocytic leukemia) Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Veenat 400 Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated. In Gastrointestinal stromal tumour A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs most commonly in the stomach or small intestine. The tumors develop into the specialized cells called interstitial cells of Cajal (ICCs). Veenat 400 Tablet helps to kill the cancer cells and also stops their further growth and spread. Follow your doctor’s instructions carefully to get the most benefit. 

Side Effects Of Veenat Tablet: 
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Veenat Edema (swelling) Nausea Vomiting Muscle cramp Musculoskeletal (bone, muscle or joint) pain Diarrhea Rash Fatigue Abdominal pain. 

How To Use Veenat Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Veenat 400 Tablet is to be taken with food. 

How Veenat Tablet Works: 
Veenat 400 Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells).

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Herduo (Lapatinib 250mg )Tablet is a prescription medicine manufactured by Natco Pharma Limited that interferes with the growth and spread of cancer cells in the body. 

Uses of Herduo Tablet: 
Herduo 250mg Tablet is used to treat a certain type of breast cancer (HER2-positive). 

How to use Lapatinib Tablet: 
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Take the tablet by mouth 1 hour before or 1 hour after a meal, but it is better to take it at a fixed time.

How Herduo Tablet Works:
Tykerb 250 mg Tablet is a HER2 inhibitor that works by interfering with HER2-related kinases inside the cell, limiting the amount of energy breast cancer cells have to grow and multiply. By limiting the amount of energy, it can slow or stop the growth of breast cancer. 

Herduo Tablet Side Effects :
Nausea, vomiting, upset stomach, mouth sores, mild rash, dry skin, trouble sleeping, etc.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Storage:
Store at room temperature. Protect from direct sunlight.

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Imatinib Capsules IP tablet is used in the treatment of blood cancers, bone marrow disorders, skin cancer and certain tumours of the stomach and the digestive tract.
Imatinib Mesylate belongs to a class of medications called kinase inhibitors. It works by preventing abnormal protein activity which signals cancer cells to multiply and spread across the body, thus inhibiting the growth of these abnormal cells.

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Evermil (Everolimus 10mg) 10 Tablet is used for the prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ. It is also used in combination with other medicines to treat cancers of breast, pancreas, lungs, and kidney. Evermil 10 Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body. The common side effects of this medicine are weakness, sinus inflammation, infection, fever, cough, etc. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions (rash, shortness of breath, coughing, swelling, etc.). Always seek medical advice if you have increased thirst or increased frequency of urination, suffer from shortness of breath, cough or fever, or need to receive any vaccination after taking this medication. Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. It may affect male or female fertility, so consult the doctor if you are planning to have a child. 

Uses Of Evermil Tablet: 
Prevention of organ rejection in transplant patients Treatment of Breast cancer Treatment of Pancreatic cancer Treatment of Lung cancer Treatment of Kidney cancer. 

Benefits Of Evermil Tablet: 
In Prevention of organ rejection in transplant patients Evermil 10 Tablet is used with other medications to prevent organ transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving any organ transplants, like kidney, liver, heart etc. This medicine reduces the activity of a person's own immune system and prevents any such rejection. In Treatment of Breast cancer Evermil 10 Tablet is used to treat breast cancer in postmenopausal women when other medicines have failed to show significant improvement. It helps to stop cancer growth and further spread and relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. Take is as advised to get maximum relief. In Treatment of Pancreatic cancer Pancreas are very essential for digestion of whatever you eat and also for metabolism of blood sugar levels as they produce the body’s natural insulin. This medicine will help to control pancreatic cancer, and will relieve the symptoms such as, lack of appetite or unexplained weight loss. Evermil 10 Tablet helps to stop the action of those chemicals that aid in pancreatic cancer growth and spread. It will help you live a longer and healthier life. In Treatment of Lung cancer Evermil 10 Tablet reduces the blood supply to the cancer cells and stops its growth. But, as it reduces the immunity, avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to. Take a healthy diet and keep taking the medicine as prescribed to get the full benefits. In Treatment of Kidney cancer Evermil 10 Tablet is used to treat kidney cancer when other medicines have failed to work. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover. Take it as prescribed to get the maximum benefit.

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TYKERB (lapatinib 250mg) is indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress human epidermal growth factor receptor 2 (HER2) and who have received prior therapy including an anthracycline, a taxane, and trastuzumab. Limitations of use: Patients should have disease progression on trastuzumab prior to initiation of treatment with TYKERB in combination with capecitabine. TYKERB is indicated in combination with letrozole for the treatment of postmenopausal women with hormone-receptor positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated. TYKERB in combination with an aromatase inhibitor has not been compared to a trastuzumab-containing chemotherapy regimen for the treatment of metastatic breast cancer. 

Important Safety Warning: Hepatotoxicity has been observed in clinical trials and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain. Contraindication: TYKERB is contraindicated in patients with known severe hypersensitivity (eg, anaphylaxis) to this product or any of its components. Decreased Left Ventricular Ejection Fraction (LVEF): TYKERB has been reported to decrease LVEF. In clinical trials, >57% of LVEF decreases occurred within the first 12 weeks of treatment. Use caution if administering to patients with conditions that could impair LVEF. Confirm normal LVEF before starting TYKERB, and continue evaluations during treatment. Hepatotoxicity: Hepatotoxicity [alanine transaminase (ALT) or aspartate transaminase (AST) >3 times the upper limit of normal (ULN) and total bilirubin >2 times the ULN] has been observed in clinical trials (<1% of patients) and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain. The hepatotoxicity may occur days to several months after initiation of treatment. Liver function tests (transaminases, bilirubin, and alkaline phosphatase) should be monitored before initiation of treatment, every 4 to 6 weeks during treatment, and as clinically indicated. If changes in liver function are severe, therapy with TYKERB should be discontinued and patients should not be retreated with TYKERB. Patients With Severe Hepatic Impairment: If TYKERB is to be administered to patients with severe preexisting hepatic impairment, dose reduction should be considered. Diarrhea: Diarrhea has been reported during treatment with TYKERB. The diarrhea may be severe, and deaths have been reported. Diarrhea generally occurs early during treatment with TYKERB, with almost half of those patients with diarrhea first experiencing it within 6 days. This usually lasts 4 to 5 days. Lapatinib-induced diarrhea is usually low-grade, with grade 3 and 4 diarrhea occurring in <10% and <1% of patients, respectively. Prompt treatment of diarrhea with antidiarrheal agents (such as loperamide) after the first unformed stool is recommended. Severe cases of diarrhea may require administration of oral or intravenous electrolytes and fluids, use of antibiotics such as fluoroquinolones (especially if diarrhea is persistent beyond 24 hours, there is fever, or grade 3 or 4 neutropenia), and interruption or discontinuation of therapy with TYKERB. Interstitial Lung Disease/Pneumonitis: TYKERB has been associated with interstitial lung disease and pneumonitis. Patients should be monitored for pulmonary symptoms indicative of interstitial lung disease or pneumonitis. Discontinue TYKERB in patients who experience pulmonary symptoms indicative of greater than or equal to grade 3 interstitial lung disease/pneumonitis.

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Pivikto (Alpelisib 150mg) tablets is contraindicated in patients with severe hypersensitivity to it or any of its componentsIndicationPivikto (Alpelisib 150mg) tablets is indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on or after an endocrine-based regimen.Important Safety InformationAlpelisib is contraindicated in patients with severe hypersensitivity to it or any of its components.Severe Hypersensitivity: Severe hypersensitivity reactions, including anaphylaxis and anaphylactic shock, can occur in patients treated with Pivikto . Severe hypersensitivity reactions were manifested by symptoms including, but not limited to, dyspnea, flushing, rash, fever, or tachycardia. The incidence of grade 3 and 4 hypersensitivity reactions was 0.7%. Advise patients of the signs and symptoms of severe hypersensitivity reactions. Permanently discontinue Alpelisib in the event of severe hypersensitivity.Severe Cutaneous Adverse Reactions (SCARs): SCARs including Stevens-Johnson syndrome (SJS), erythema multiforme (EM), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) can occur in patients treated with Pivikto . In the SOLAR-1 study, SJS and EM were reported in 0.4% and 1.1% of patients, respectively. DRESS was reported in patients in the postmarketing setting. If signs or symptoms of SCARs occur, interrupt Alpelisib until the etiology of the reaction has been determined. Consultation with a dermatologist is recommended.If a SCAR is confirmed, permanently discontinue Pivikto . Do not reintroduce Alpelisib in patients who have experienced previous SCARs during Alpelisib treatment. If it is not confirmed, Alpelisib may require dose modifications, topical corticosteroids, or oral antihistamine treatment.Advise patients of the signs and symptoms of SCARs (eg, a prodrome of fever, flu-like symptoms, mucosal lesions, progressive skin rash, or lymphadenopathy).Hyperglycemia: Severe hyperglycemia, including ketoacidosis, can occur in patients treated with Pivikto . Hyperglycemia was reported in 65% of patients treated with Pivikto . Grade 3 (FPG >250-500 mg/dL) and grade 4 (FPG >500 mg/dL) hyperglycemia were reported in 33% and 3.9% of patients, respectively. Ketoacidosis was reported in 0.7% of patients (n=2) treated with Pivikto .Before initiating treatment with Pivikto , test fasting plasma glucose (FPG), HbA1c, and optimize blood glucose. After initiating treatment with Pivikto , monitor fasting glucose (FPG or fasting blood glucose) at least once every week for the first 2 weeks, then at least once every 4 weeks, and as clinically indicated. Monitor HbA1c every 3 months and as clinically indicated. If a patient experiences hyperglycemia after initiating treatment with Pivikto , monitor fasting glucose as clinically indicated, and at least twice weekly until fasting glucose decreases to normal levels. During treatment with antidiabetic medication, continue monitoring fasting glucose at least once a week for 8 weeks, followed by once every 2 weeks and as clinically indicated. Consider consultation with a health care practitioner with expertise in the treatment of hyperglycemia and counsel patients on lifestyle changes.The safety of Alpelisib in patients with type 1 and uncontrolled type 2 diabetes has not been established as these patients were excluded from the SOLAR-1 trial. Patients with a medical history of type 2 diabetes were included. Patients with a history of diabetes mellitus may require intensified diabetic treatment. Closely monitor patients with diabetes.

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Lynide ( Lynideomide 5mg ,10mg ,25mg)is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). Lynide should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if Lynide is safe and effective in children.What is the most important information I should know about Lynide?Before you begin taking Lynide, you must read and agree to all of the instructions in the Lynide REMS program. Before prescribing Lynide, your healthcare provider will explain the Lynide REMS program to you and have you sign the Patient-Physician Agreement Form.
Lynide may cause serious side effects, including:
Possible birth defects (deformed babies) or death of an unborn baby. Females who are pregnant or who plan to become pregnant must not take Lynide.
Lynide is similar to the medicine thalidomide which is known to cause severe life-threatening birth defects. Lynide has not been tested in pregnant females. Lynide has harmed unborn animals in animal testing.Females must not get pregnant:For at least 4 weeks before starting LynideWhile taking LynideDuring any breaks (interruptions) in your treatment with LynideFor at least 4 weeks after stopping LynideFemales who can become pregnant:
Must have pregnancy tests weekly for 4 weeks, then every 4 weeks if your menstrual cycle is regular, or every 2 weeks if your menstrual cycle is irregular.If you miss your period or have unusual bleeding, you will need to have a pregnancy test and receive counseling.Must agree to use 2 different forms of effective birth control at the same time, for at least 4 weeks before, while taking, during any breaks (interruptions) in your treatment, and for at least 4 weeks after stopping Lynide.Talk with your healthcare provider to find out about options for effective forms of birth control that you may use to prevent pregnancy before, during, and after treatment with Lynide.If you had unprotected sex or if you think your birth control has failed, stop taking Lynide immediately and call your healthcare provider right away.If you become pregnant while taking Lynide, stop taking it right away and call your healthcare provider. If your healthcare provider is not available, you can call Celgene Customer Care Center at 1-888-423-5436. Healthcare providers and patients should report all cases of pregnancy to:
FDA MedWatch at 1-800-FDA-1088, andCelgene Corporation, a Bristol Myers Squibb company, at 1-888-423-5436.There is a pregnancy exposure registry that monitors the outcomes of females who take Lynide during pregnancy, or if their male partner takes Lynide and they are exposed during pregnancy. You can enroll in this registry by calling Celgene Corporation, a Bristol Myers Squibb company, at the phone number listed above.
Lynide can pass into human semen:
Males, including those who have had a vasectomy, must always use a latex or synthetic condom during any sexual contact with a pregnant female or a female that can become pregnant while taking Lynide, during any breaks (interruptions) in your treatment with Lynide, and for up to 4 weeks after stopping Lynide.Do not have unprotected sexual contact with a female who is or could become pregnant. Tell your healthcare provider if you do have unprotected sexual contact with a female who is or could become pregnant.Do not donate sperm while taking Lynide, during any breaks (interruptions) in your treatment, and for 4 weeks after stopping Lynide. If a female becomes pregnant with your sperm, the baby may be exposed to Lynide and may be born with birth defects.Men: If a female becomes pregnant with your sperm, you should call your HCP right away.

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SPNIB (Dasatinib 70mg) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.
SPNIB 70 mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. 

Uses Of Spinab Tablet:
Blood cancer (Chronic myeloid leukaemia).

Benefits Of Spinab Tablet:
In Blood cancer (Chronic myeloid leukaemia)Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. SPNIB 70 mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side Effects Of Spinab Tablet:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about themCommon side effects of SPNIBAbdominal painAnemia (low number of red blood cells)Breathing problemsFatigueFeverHeadacheInfectionLow blood plateletsMusculoskeletal (bone, muscle or joint) painNauseaRashVomiting

How To Use Spinab Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. SPNIB 70 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Spinab Tablet Works:
SPNIB 70 mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety Advice:

• It is not known whether it is safe to consume alcohol with SPNIB 70 mg Tablet. 
• SPNIB 70 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. 
• SPNIB 70 mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
• SPNIB 70 mg Tablet may cause side effects which could affect your ability to drive.Take special care when driving in case you experience side effects such as dizziness and blurred vision with SPNIB 70 mg Tablet.

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ERLEADA (Apalutamide 60 mg) is a prescription medicine used for the treatment of prostate cancer:
that has spread to other parts of the
body and still responds to a medical or surgical treatment that lowers testosterone,OR
that has not spread to other parts of the body and no longer responds to a medical or surgical treatment that lowers testosterone.It is not known if ERLEADA® is safe and effective in females.
It is not known if ERLEADA® is safe and effective in children.
IMPORTANT SAFETY INFORMATIONBefore taking ERLEADA®, tell your healthcare provider about all your medical conditions, including if you:
have a history of heart diseasehave high blood pressurehave diabeteshave abnormal amounts of fat or cholesterol in your blood (dyslipidemia)have a history of seizures, brain injury, stroke, or brain tumorsare pregnant or plan to become pregnant. ERLEADA® can cause harm to your unborn baby and loss of pregnancy (miscarriage).have a partner who is pregnant or may become pregnant.Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 3 months after the last dose of ERLEADA®.Males should use a condom during sex with a pregnant female.Talk with your healthcare provider if you have questions about birth control.
are breastfeeding or plan to breastfeed. It is not known if ERLEADA® passes into breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ERLEADA® can interact with many other medicines.
You should not start or stop any medicine before you talk with the healthcare provider that prescribed ERLEADA®.
Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.
How should I take ERLEADA®?
Take ERLEADA® exactly as your healthcare provider tells you.Your healthcare provider may change your dose if needed.Do not stop taking your prescribed dose of ERLEADA® without talking with your healthcare provider first.Take your prescribed dose of ERLEADA® 1 time a day, at the same time each day.Take ERLEADA® with or without food.Swallow ERLEADA® tablets whole.If you miss a dose of ERLEADA®, take your normal dose as soon as possible on the same day. Return to your normal schedule on the following day. You should not take extra tablets to make up the missed dose.You should start or continue a gonadotropin-releasing hormone (GnRH) analog therapy during your treatment with ERLEADA® unless you have had a surgery to lower the amount of testosterone in your body (surgical castration).If you take too much ERLEADA®, call your healthcare provider or go to the nearest hospital emergency room.What are the possible side effects of ERLEADA®?
ERLEADA® may cause serious side effects including:
Heart Disease, Stroke, or Mini-Stroke. Bleeding in the brain or blockage of the arteries in the heart or in part of the brain have happened in some people during treatment with ERLEADA® and can lead to death. Your healthcare provider will monitor you for signs and symptoms of heart or brain problems during your treatment with ERLEADA®. Call your healthcare provider or get medical help right away if you get:chest pain or discomfort at rest or with activityshortness of breathnumbness or weakness of the face, arm, or leg, especially on one side of the bodytrouble talking or understandingtrouble seeing in one or both eyesdizziness, loss of balance or coordination, or trouble walkingFractures and Falls.