Anti Cancer Medicines

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Nintedanib, sold under the brand names BDR and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.

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Azacitidine (trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative, decitabine are used in the treatment of myelodysplastic syndrome. Both drugs were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.

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XTANDI (Enzalutamide 40mg) is a prescription medicine used to treat men with prostate cancer that: 
No longer responds to a hormone therapy or surgical treatment to lower testosterone or has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone. It is not known if XTANDI is safe and effective in females or children. XTANDI is an androgen receptor inhibitor. Androgens are a group of hormones that includes testosterone. Androgen receptor inhibitors interfere with the connection between androgens and androgen receptors. This can help slow cancer cell growth

Important Safety Information
What should I tell my doctor before taking XTANDI?
Tell your doctor about all your medical conditions, including if you:Have a history of seizures, brain injury, stroke, or brain tumors.Have a history of heart disease, have high blood pressure, or have abnormal amounts of fat or cholesterol in your blood (dyslipidemia). Are pregnant or plan to become pregnant. XTANDI can cause harm to your unborn baby and loss of pregnancy (miscarriage). Have a partner who is pregnant or may become pregnant.Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with XTANDI and for 3 months after the last dose. Males must use a condom during sex with a pregnant female. Are breast feeding or plan to breastfeed. It is not known if XTANDI passes into your breast milk. Take other medicines. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. These include prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not start or stop any medicine without talking to your doctor.

How should I take XTANDI?
Take XTANDI exactly as your doctor tells you. Take your prescribed dose once a day, at the same time each day. XTANDI can be taken with or without food. Swallow XTANDI capsules or tablets whole. Do not chew, dissolve, or open the capsules. Do not cut, crush or chew the tablets. Your doctor may change your dose if needed. Do not change or stop taking your prescribed dose of XTANDI without talking with your doctor first. If you are receiving gonadotropin-releasing hormone (GnRH) therapy, you should continue with this treatment while taking XTANDI unless you have had surgery to lower the amount of testosterone in your body (surgical castration). If you miss a dose of XTANDI: Take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI each day. If you take too much XTANDI: Call your doctor or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

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Indenza 40 mg (Enzalutamide) is an androgen receptor (AR) inhibitor indicated for patients suffering from prostate cancer types such as,

• Metastatic castration-resistant prostate cancer where other chemotherapy options (docetaxel) did not work. (cancer that lowers the growth of testosterone, a male hormone)
• Metastatic castration-sensitive prostate cancer where other hormonal therapy did not work (cancer that spreads to other parts of the body)

Peculiar properties of Indenza 40 mg (Enzalutamide) that helps in slowing down the growth of prostate cancer,

• Obstructs the communication tool of cancer cells (AR signaling i.e. binding with androgen receptor and interaction with DNA)
• Hinders the unwanted growth (Cell proliferation) of androgen (testosterone)
• Induces the act of self-destruction of cells (Apoptosis)
• Reduces the risk of progression and death
• Postpones the requirement of chemotherapy

Administration of Indenza 40 mg (Enzalutamide):

Indenza 40 mg (Enzalutamide) is given orally in a 160 mg dosage (4×40 mg) once in 24 hours with or without food. If patients experience any sort of side-effects, the dosage can be modified and reduced to 120 mg (3×40 mg) or 80 mg (2×40 mg).

Once swallowed, enzalutamide is readily soluble (bio-available) in the body within 3 hours. It is metabolized in the liver and then distributed throughout the region of cancer with a high binding affinity (97%) to cancer cells. Once enzalutamide completes its activities, more than 50% of the dose is expelled from the body in between 3 to 11 days.

When should Indenza 40 mg (Enzalutamide) be avoided or used cautiously?

• If patients have a history of or experience sudden unwarranted changes in behaviour caused due to disturbances in the brain (Seizures)
• If patients are confirmed with symptoms like headache, impaired vision and low blood pressure (Posterior reversible encephalopathy syndrome)
• If patients are seen with kidney diseases (severe renal impairment and end-stage renal disease)
• If patients show signs of severe disease of the liver
• If patients are seen with a relative risk of heart diseases
• If patients are allergic to dosage and show symptoms like tongue, lip, or pharyngeal swelling (edema)
• If patients are intolerant to lactose

Side-effects of Indenza 40 mg (Enzalutamide):
Most common side-effects:

• Tiredness (Fatigue)
• Pain in the back, muscles, bones and joints
• Diarrhea
• Weakness in the muscles
• Dizziness
• Swelling (edema) in the hands and legs
• Severe headache
• Cold-like symptoms
• Anxiety or stress

Other side-effects:

• Discoloured urine in pink or red colour (Hematuria)
• Rashes on skin
• Trouble in falling asleep (insomnia)
• Trouble in breathing (pneumonia)
• Weakness in the legs
• Pain in the lower back
• High blood pressure (Hypertension)
• Burning or numbness of skin (paresthesia)
• Excitement or confusion
• Loss of memory
• Nightmares

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Enzamide (Enzalutamide 40mg) Tablet is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

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Rucaparib 200 Mg tablets are a prescription medicine used in adults for:the maintenance treatment of ovarian cancer, fallopian tube cancer, or primary peritoneal cancer whose cancer has come back and who are in response (complete or partial response) to a platinum-based chemotherapythe treatment of ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have certain “BRCA” gene mutations, either inherited (germline) or acquired (somatic), and who have been treated with 2 or more chemotherapy medicines for their cancer. Your healthcare provider will perform a test to make sure Rucaparib 200 Mg is right for you.the treatment of castration-resistant prostate cancer (prostate cancer that no longer responds to medical or surgical treatment that lowers testosterone):that has spread to other parts of the body, andhas a certain type of inherited (germline) or acquired (somatic) abnormal BRCA gene, and you have been treated with certain medicines for your cancer.Rucaparib 200 Mg was approved based on response rate and how long patients’ responses lasted. There are ongoing studies to confirm the clinical benefit of Rucaparib 200 Mg. Your healthcare provider will perform a test to make sure Rucaparib 200 Mg is right for you.It is not known if Rucaparib 200 Mg is safe and effective in children.SELECT IMPORTANT SAFETY INFORMATIONWhat Warnings should I know about Rucaparib 200 Mg?Rucaparib 200 Mg tablets may cause serious side effects including bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of cancer of the blood called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during or after treatment with Rucaparib 200 Mg, although MDS or AML was not observed in men with prostate cancer during the clinical study. MDS or AML may lead to death. If you develop MDS or AML, your healthcare provider will stop treatment with Rucaparib 200 Mg. You should not use Rucaparib 200 Mg if:You are pregnant or plan to become pregnant. Rucaparib 200 Mg can harm your unborn baby and may cause loss of pregnancy (miscarriage). You should not become pregnant during treatment with Rucaparib 200 Mg.If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with Rucaparib 200 Mg.Females who are able to become pregnant should use effective birth control during treatment and for at least 6 months after receiving the last dose of Rucaparib 200 Mg.Talk to your healthcare provider about birth control methods that may be right for you.Tell your healthcare provider right away if you become pregnant.You are breastfeeding or plan to breastfeed. It is not known if Rucaparib 200 Mg passes into breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose of Rucaparib 200 Mg. Talk to your healthcare provider about the best way to feed your baby during this time.If you are a male with a female partner who is pregnant or able to become pregnant. Effective birth control should be used during treatment and for 3 months after the last dose of Rucaparib 200 Mg. Do not donate sperm during use and for 3 months after the last dose of Rucaparib 200 Mg.What other important information should I know about Rucaparib 200 Mg?Your healthcare provider will do blood tests before, and every month during treatment with Rucaparib 200 Mg to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts for a long time. Your healthcare provider may stop treatment with Rucaparib 200 Mg until your blood cell counts improve. Avoid spending time in sunlight while on Rucaparib 200 Mg since your skin may become more sensitive to the sun and may sunburn more easily.

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Calquence (Acalabrutinib 100mg) is the generic name for the trade name drug Calquence. In some cases, health care professionals may use the trade name Calquence when referring to the generic drug name acalabrutinib. Drug Type: Acalabrutinib is a targeted therapy. Acalabrutinib inhibits the function of Bruton's tyrosine kinase (BTK) (for more detail, see "How Acalabrutinib Works" below). What Acalabrutinib Is Used For The treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. The treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. How Acalabrutinib Is Given Acalabrutinib is a 100 mg capsule, taken by mouth twice daily. Take acalabrutinib approximately 12 hours apart at the same time each day. Swallow acalabrutinib capsules whole with at least 8 ounces of water. Do not crush, open, chew or dissolve capsules. Take acalabrutinib with or without food. If you miss a dose by more than 3 hours, omit that dose and take the next dose at the regularly scheduled time; do not take extra doses to make up for a missed dose. The amount of acalabrutinib that you will receive depends on many factors including your general health or other health problems, other medications you may be taking, and severity or tolerance of side effects. Your doctor will determine your exact dosage and schedule. Side Effects Important things to remember about the side effects of acalabrutinib: Most people will not experience all of the acalabrutinib side effects listed. Acalabrutinib side effects are often predictable in terms of their onset, duration, and severity. Acalabrutinib side effects are almost always reversible and should improve after treatment is stopped Acalabrutinib side effects may be quite manageable. There are many options to minimize or prevent the side effects of acalabrutinib. There is no relationship between the presence and/or severity of side effects and the effectiveness of the medication. Always report side effects to your healthcare provider. The following side effects are common (occurring in greater than 30%) for patients taking acalabrutinib: Headache Diarrhea These are less common side effects (occurring in 10-29%) for patients receiving acalabrutinib: Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for infection, anemia and/or bleeding. Fatigue Bruising Muscle pain Nausea Rash Abdominal pain Constipation Vomiting A rare, but potentially serious side effect of acalabrutinib is heart rhythm changes (arrhythmias), including atrial fibrillation and atrial flutter. Not all side effects are listed above. Side effects that are very rare - occurring in less than about 10 percent of patients - are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms. When to Contact Your Health Care Provider Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Fever of 100.4º F (38º C) or higher, chills Shortness of breath, cough or trouble breathing Any bleeding that won't stop The following symptoms require medical attention, but are not an emergency.

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Ibrunat 140 mg Uses
Ibrunat is kind of a medicine which is prescribed for treating adult patients who has the following types of blood cancers:

• Mantle cell lymphoma
• Waldenstrom’s macroglobulinemia
• Chronic Graft Versus Host Disease
• Chronic lymphocytic leukemia and
• Marginal zone lymphoma (MZL)
• Small Lymphocytic Lymphoma

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Lynide ( Lynideomide 5mg ,10mg ,25mg)is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). Lynide should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if Lynide is safe and effective in children.What is the most important information I should know about Lynide?Before you begin taking Lynide, you must read and agree to all of the instructions in the Lynide REMS program. Before prescribing Lynide, your healthcare provider will explain the Lynide REMS program to you and have you sign the Patient-Physician Agreement Form.
Lynide may cause serious side effects, including:
Possible birth defects (deformed babies) or death of an unborn baby. Females who are pregnant or who plan to become pregnant must not take Lynide.
Lynide is similar to the medicine thalidomide which is known to cause severe life-threatening birth defects. Lynide has not been tested in pregnant females. Lynide has harmed unborn animals in animal testing.Females must not get pregnant:For at least 4 weeks before starting LynideWhile taking LynideDuring any breaks (interruptions) in your treatment with LynideFor at least 4 weeks after stopping LynideFemales who can become pregnant:
Must have pregnancy tests weekly for 4 weeks, then every 4 weeks if your menstrual cycle is regular, or every 2 weeks if your menstrual cycle is irregular.If you miss your period or have unusual bleeding, you will need to have a pregnancy test and receive counseling.Must agree to use 2 different forms of effective birth control at the same time, for at least 4 weeks before, while taking, during any breaks (interruptions) in your treatment, and for at least 4 weeks after stopping Lynide.Talk with your healthcare provider to find out about options for effective forms of birth control that you may use to prevent pregnancy before, during, and after treatment with Lynide.If you had unprotected sex or if you think your birth control has failed, stop taking Lynide immediately and call your healthcare provider right away.If you become pregnant while taking Lynide, stop taking it right away and call your healthcare provider. If your healthcare provider is not available, you can call Celgene Customer Care Center at 1-888-423-5436. Healthcare providers and patients should report all cases of pregnancy to:
FDA MedWatch at 1-800-FDA-1088, andCelgene Corporation, a Bristol Myers Squibb company, at 1-888-423-5436.There is a pregnancy exposure registry that monitors the outcomes of females who take Lynide during pregnancy, or if their male partner takes Lynide and they are exposed during pregnancy. You can enroll in this registry by calling Celgene Corporation, a Bristol Myers Squibb company, at the phone number listed above.
Lynide can pass into human semen:
Males, including those who have had a vasectomy, must always use a latex or synthetic condom during any sexual contact with a pregnant female or a female that can become pregnant while taking Lynide, during any breaks (interruptions) in your treatment with Lynide, and for up to 4 weeks after stopping Lynide.Do not have unprotected sexual contact with a female who is or could become pregnant. Tell your healthcare provider if you do have unprotected sexual contact with a female who is or could become pregnant.Do not donate sperm while taking Lynide, during any breaks (interruptions) in your treatment, and for 4 weeks after stopping Lynide. If a female becomes pregnant with your sperm, the baby may be exposed to Lynide and may be born with birth defects.Men: If a female becomes pregnant with your sperm, you should call your HCP right away.

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Lenalid (Lenalidomide 5mg ,10mg,  25mg)is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). Lenalid should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if Lenalid is safe and effective in children.

What is the most important information I should know about Lenalid?
Before you begin taking Lenalid, you must read and agree to all of the instructions in the Lenalid REMS program. Before prescribing Lenalid, your healthcare provider will explain the Lenalid REMS program to you and have you sign the Patient-Physician Agreement Form.

Lenalid may cause serious side effects, including:
Possible birth defects (deformed babies) or death of an unborn baby. Females who are pregnant or who plan to become pregnant must not take Lenalid.

Lenalid is similar to the medicine thalidomide which is known to cause severe life-threatening birth defects. Lenalid has not been tested in pregnant females. Lenalid has harmed unborn animals in animal testing.Females must not get pregnant:For at least 4 weeks before starting LenalidWhile taking LenalidDuring any breaks (interruptions) in your treatment with LenalidFor at least 4 weeks after stopping LenalidFemales who can become pregnant:
Must have pregnancy tests weekly for 4 weeks, then every 4 weeks if your menstrual cycle is regular, or every 2 weeks if your menstrual cycle is irregular.If you miss your period or have unusual bleeding, you will need to have a pregnancy test and receive counseling. Must agree to use 2 different forms of effective birth control at the same time, for at least 4 weeks before, while taking, during any breaks (interruptions) in your treatment, and for at least 4 weeks after stopping Lenalid. Talk with your healthcare provider to find out about options for effective forms of birth control that you may use to prevent pregnancy before, during, and after treatment with Lenalid. If you had unprotected sex or if you think your birth control has failed, stop taking Lenalid immediately and call your healthcare provider right away. If you become pregnant while taking Lenalid, stop taking it right away and call your healthcare provider.

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Nintib (Nintedanib  100mg , 150mg) is a prescription medicine used:to treat people with a lung disease called idiopathic pulmonary fibrosis (IPF).to treat people with a chronic (long lasting) interstitial lung disease in which lung fibrosis continues to worsen (progress).to slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD) (also known as scleroderma-associated ILD).It is not known if Nintib is safe and effective in children.What are the possible side effects of Nintib?Nintib may cause serious side effects, including:See “What is the most important information I should know about Nintib?”liver problems. Call your doctor right away if you have unexplained symptoms such as yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea colored) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal, feeling tired, or loss of appetite. Your doctor will do blood tests to check how well your liver is working before starting and during your treatment with Nintib.diarrhea, nausea, and vomiting. While you are taking Nintib, your doctor may recommend that you drink fluids or take medicine to treat these side effects. Tell your doctor if you have diarrhea, nausea, or vomiting or if these symptoms do not go away or become worse. Tell your doctor if you are taking over-the-counter laxatives, stool softeners, and other medicines or dietary supplements that can cause diarrhea.heart attack. Tell your doctor right away if you have symptoms of a heart problem. These symptoms may include chest pain or pressure, pain in your arms, back, neck or jaw, or shortness of breath.stroke. Tell your doctor right away if you have symptoms of a stroke. These symptoms may include numbness or weakness on 1 side of your body, trouble talking, headache, or dizziness.bleeding problems. Nintib may increase your chances of having bleeding problems. Tell your doctor if you have unusual bleeding, bruising, or wounds that do not heal. Tell your doctor if you are taking a blood thinner, including prescription blood thinners and over-the-counter aspirin.tear in your stomach or intestinal wall (perforation). Nintib may increase your chances of having a tear in your stomach or intestinal wall. Tell your doctor if you have pain or swelling in your stomach area.The most common side effects of Nintib are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure.

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Pomalidomide (1mg, 2mg, 4mg)is a prescription medicine used to treat adults with:
Multiple myeloma. Pomalidomide is taken along with the medicine dexamethasone, in people who:have received at least 2 prior medicines to treat multiple myeloma, including a type of medicine known as a proteasome inhibitor and lenalidomide, andtheir disease has become worse during treatment or within 60 days of finishing the last treatmentAIDS-related Kaposi sarcoma (KS). Pomalidomide is taken when highly active antiretroviral therapy (HAART) has not worked well enough or stopped working (failed)KS who do not have HIV infection (HIV negative).It is not known if Pomalidomide is safe and effective in children.
Who should not take Pomalidomide?
Do not take Pomalidomide if you:
are pregnant, plan to become pregnant, or become pregnant during treatment with Pomalidomide. See “What is the most important information I should know about Pomalidomide?”are allergic to pomalidomide or any of the ingredients in Pomalidomide. See the end of this Medication Guide for a complete list of ingredients in Pomalidomide.What are the possible side effects of Pomalidomide?
Pomalidomide can cause serious side effects, including:
Low white blood cells (neutropenia), low platelets (thrombocytopenia), and low red blood cells (anemia) arecommon with Pomalidomide, but can also be serious. You may need a blood transfusion or certain medicines if your blood counts drop too low. Your blood counts should be checked weekly for the first 8 weeks of treatment and monthly after that.Severe liver problems, including liver failure and death. Your healthcare provider should do blood tests to check your liver function during your treatment with Pomalidomide. Tell your healthcare provider right away if you develop any of the following symptoms of liver problems:Yellowing of your skin or the white part of your eyes (jaundice)Dark or brown (tea-colored) urinePain on the upper right side of your stomach area (abdomen)Bleeding or bruising more easily than normalFeeling very tiredSevere allergic reactions and severe skin reactions can happen with Pomalidomide and may cause death.Call your healthcare provider if you develop any of the following signs or symptoms during treatment with Pomalidomide:
a red, itchy, skin rashpeeling of your skin or blisterssevere itchingfeverGet emergency medical help right away if you develop any of the following signs or symptoms during treatment with Pomalidomide:
swelling of your lips, mouth, tongue, or throattrouble breathing or swallowingraised red areas on your skin (hives)a very fast heartbeatyou feel dizzy or faintDizziness and confusion. See “What should I avoid while taking Pomalidomide?Nerve damage. Stop taking Pomalidomide and call your healthcare provider if you develop symptoms of nerve damage including: numbness, tingling, pain, burning sensation in your hands, legs, or feet.Risk of new cancers (malignancies). New cancers, including certain blood cancers (acute myelogenous leukemia or AML) have been seen in people who received Pomalidomide. Talk with your healthcare provider about your risk of developing new cancers if you take Pomalidomide.Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer cells. TLS can cause kidney failure and the need for dialysis treatment, abnormal heart rhythm, seizure, and sometimes death. Your healthcare provider may do blood tests to check you for TLS.Your healthcare provider may tell you to stop taking Pomalidomide if you develop certain serious side effects during treatment.
The most common side effects of Pomalidomide in people with Multiple Myeloma include:
tiredness and weaknessconstipationnauseadiarrheashortness of breathupper respiratory tract infectionback painfever.

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TENOFOVIR DISOPROXIL FUMARATE helps manage the symptoms of HIV infection. It may also be used for PrEP (pre-exposure prophylaxis), which lowers the risk of getting HIV through sex. It works by limiting the spread of HIV in the bo

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IMFINZI (Durvalumab 120mg) is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death.

You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended. Lung problems icon Lung problems: cough, shortness of breath, and chest pain Intestinal problems icon Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness Liver problems icon Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach-area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal Hormone gland problems icon Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increase sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness Kidney problems icon Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite Skin problems icon Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes Other organ problems icon Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI.

Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs; double vision, blurry vision, sensitivity to light, eyepain, changes in eyesight; persistent or severe muscle pain or weakness, muscle cramps; and low red blood cells, bruising Infusion icon Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications. Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI if you have severe side effects.

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Evertor (Everolimus 10mg) Tablet is used for the prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ. It is also used in combination with other medicines to treat cancers of breast, pancreas, lungs, and kidney. Evertor 10mg Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body. The common side effects of this medicine are weakness, sinus inflammation, infection, fever, cough, etc. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions (rash, shortness of breath, coughing, swelling, etc.). Always seek medical advice if you have increased thirst or increased frequency of urination, suffer from shortness of breath, cough or fever, or need to receive any vaccination after taking this medication. Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. It may affect male or female fertility, so consult the doctor if you are planning to have a child.

Uses Of Evertor Tablet:
Prevention of organ rejection in transplant patients Treatment of Breast cancer Treatment of Pancreatic cancer Treatment of Lung cancer Treatment of Kidney cancer.

Benefits Of Evertor Tablet:
In Prevention of organ rejection in transplant patients Evertor 10mg Tablet is used with other medications to prevent organ transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving any organ transplants, like kidney, liver, heart etc. This medicine reduces the activity of a person's own immune system and prevents any such rejection. In Treatment of Breast cancer Evertor 10mg Tablet is used to treat breast cancer in postmenopausal women when other medicines have failed to show significant improvement. It helps to stop cancer growth and further spread and relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. Take is as advised to get maximum relief. In Treatment of Pancreatic cancer Pancreas are very essential for digestion of whatever you eat and also for metabolism of blood sugar levels as they produce the body’s natural insulin. This medicine will help to control pancreatic cancer, and will relieve the symptoms such as, lack of appetite or unexplained weight loss. Evertor 10mg Tablet helps to stop the action of those chemicals that aid in pancreatic cancer growth and spread. It will help you live a longer and healthier life. In Treatment of Lung cancer Evertor 10mg Tablet reduces the blood supply to the cancer cells and stops its growth. But, as it reduces the immunity, avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to. Take a healthy diet and keep taking the medicine as prescribed to get the full benefits. In Treatment of Kidney cancer Evertor 10mg Tablet is used to treat kidney cancer when other medicines have failed to work. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover. Take it as prescribed to get the maximum benefit.

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Evermil (Everolimus 10mg) 10 Tablet is used for the prevention of organ rejection in transplant patients. It regulates the body’s immune response, so the body can accept the new organ. It is also used in combination with other medicines to treat cancers of breast, pancreas, lungs, and kidney. Evermil 10 Tablet must be taken in a dose and duration as per the prescription. It can be taken with or without food but make sure to take it at about the same time every day. An overdose of this medicine may have serious side effects on the body. The common side effects of this medicine are weakness, sinus inflammation, infection, fever, cough, etc. If any of the side effects persist or bother you, consult the doctor immediately. Inform the doctor immediately if you experience any allergic reactions (rash, shortness of breath, coughing, swelling, etc.). Always seek medical advice if you have increased thirst or increased frequency of urination, suffer from shortness of breath, cough or fever, or need to receive any vaccination after taking this medication. Before taking this medicine, it is important to consult your doctor if you have any ongoing medication for any underlying disease. Pregnant and breastfeeding women must inform the doctor prior to the initiation of this treatment. During the treatment, your doctor may advise you for some laboratory tests to know the effects of the medicine in the body. It may affect male or female fertility, so consult the doctor if you are planning to have a child. 

Uses Of Evermil Tablet: 
Prevention of organ rejection in transplant patients Treatment of Breast cancer Treatment of Pancreatic cancer Treatment of Lung cancer Treatment of Kidney cancer. 

Benefits Of Evermil Tablet: 
In Prevention of organ rejection in transplant patients Evermil 10 Tablet is used with other medications to prevent organ transplant rejection. Rejection usually happens due to attack by the immune system of the person receiving the transplanted organ on the transplant itself, in people who are receiving any organ transplants, like kidney, liver, heart etc. This medicine reduces the activity of a person's own immune system and prevents any such rejection. In Treatment of Breast cancer Evermil 10 Tablet is used to treat breast cancer in postmenopausal women when other medicines have failed to show significant improvement. It helps to stop cancer growth and further spread and relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipple or changes in the shape or texture of the breast. Take is as advised to get maximum relief. In Treatment of Pancreatic cancer Pancreas are very essential for digestion of whatever you eat and also for metabolism of blood sugar levels as they produce the body’s natural insulin. This medicine will help to control pancreatic cancer, and will relieve the symptoms such as, lack of appetite or unexplained weight loss. Evermil 10 Tablet helps to stop the action of those chemicals that aid in pancreatic cancer growth and spread. It will help you live a longer and healthier life. In Treatment of Lung cancer Evermil 10 Tablet reduces the blood supply to the cancer cells and stops its growth. But, as it reduces the immunity, avoid being in crowds and wash your hands often to prevent any infections. Have plenty of fluids, unless otherwise advised by the doctor not to. Take a healthy diet and keep taking the medicine as prescribed to get the full benefits. In Treatment of Kidney cancer Evermil 10 Tablet is used to treat kidney cancer when other medicines have failed to work. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover. Take it as prescribed to get the maximum benefit.

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Nindanib (Nintedanib 150 Mg) Soft Gelatin Capsule is used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer.

Nindanib 150 Soft Gelatin Capsule should be taken with food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Diarrhea is a very common side effect of this medicine. You are advised to drink plenty of fluids and inform your doctor if it does not go away. Other common side effects include nausea, abdominal pain, vomiting, abnormal liver function tests, loss of appetite, headache, weight loss, and high blood pressure. Your doctor might ask you for some blood tests to monitor liver functioning.

Before taking it, tell your doctor if have a bleeding problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses Of Nindanib Soft Gelatin Capsule:

• Idiopathic pulmonary fibrosis
• Non-small cell lung cancer

Approx. Rs 15,000 / BoxGet Latest Price

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Cyendiv (Nintedanib  100mg , 150mg ) is a prescription medicine used:

• To treat people with a lung disease called idiopathic pulmonary fibrosis (IPF).
• To treat people with a chronic (long lasting) interstitial lung disease in which lung fibrosis continues to worsen (progress).
• To slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD) (also known as scleroderma-associated ILD).
• It is not known if Cyendiv is safe and effective in children.

Approx. Rs 1,000 / StripeGet Latest Price

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Glenza Capsule (Enzalutamide 40 mg) is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Glenza Capsule should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, hot flashes, weakness and high blood pressure is very common side effect of this medicine. Other than this, yellowing of skin, loss of appetite, shortness of breath, abdominal pain, dark urine, and skin rashes might be observed as side effects. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.Enzalutamide Glenza 40mg Capsules Uses : 

Enzalutamide 40mg is utilized for the treatment of metastatic maiming safe prostate growth (prostate cancer that is impervious to therapeutic or surgical medications that lower testosterone). This medication likewise keeps the androgens from working inside the prostate disease cells. 

 

Indian Enzalutamide Capsules Side Effects: 
All meds may cause symptoms, however many individuals have no, or minor, reactions. Check with your specialist if any of these most COMMON reactions hold on or wind up noticeably annoying: 

• Icy like manifestations (eg, hack, runny or stuffy nose, wheezing, sore throat); the runs; tipsiness; cerebral pain; hot flashes; mellow back, bone, joint, or, then again muscle torment; tiredness; inconvenience resting; shortcoming. 
• Look for medicinal consideration immediately if any of these SEVERE reactions happen: Serious unfavorably susceptible responses (rash; hives; tingling; trouble breathing; snugness in the chest; swelling of the mouth, face, lips, or tongue); nervousness; back torment with leg deadness or shortcoming; changes in the measure of pee delivered; perplexity or issues thinking obviously; the diminished feeling of touch; sentiment shivering, consuming, pricking, or deadness of the skin; fever, chills, or determined sore throat; visualizations; memory issues; muscle throbs or shortcoming; pink or red pee; seizures; 
• An extreme or diligent migraine; shortness of breath; swelling of the hands, arms, legs, or feet. 

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Azel (Enzalutamide 40mg) Capsule is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Azel 40mg Capsule should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, hot flashes, weakness and high blood pressure is very common side effect of this medicine. Other than this, yellowing of skin, loss of appetite, shortness of breath, abdominal pain, dark urine, and skin rashes might be observed as side effects. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

Benefits Of Azel Capsule:
In Prostate cancer Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Azel 40mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side Effects Of Azel Capsule:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

How To Use Azel Capsule:
Take this medicine in the dose and duration as advised by your doctor. Azel 40mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Azel Capsule Works:
Azel 40mg Capsule is an antiandrogens. It works by blocking the effect of the natural male hormones on the growth of prostate cells.

Approx. Rs 1,000 / StripeGet Latest Price

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Obnyx (Enzalutamide 40mg) is FDA approved generic oncology drug that is used to treat advanced forms of Prostate cancer, non-metastatic castration-resistant prostate cancer (nmCRPC).

A company statement declared that this is a drop of 70%, in comparison to the existing cost of therapy in India.

As per statement, the current MRP of Enzalutamide drug in India ranges from Rs. 70000 to Rs 80000 for a monthly therapy and can be a huge financial burden for the elderly patients as they need to continue the therapy for a long period of time. This price reduction will benefit many prostate cancer patients to adhere to the treatment.
The drug, named Enzalutamide, launched under the brand name Obnyx 40mg, will be available in soft gelatin capsules at a monthly treatment cost aprox of 357 US$.
In the U.S, Enzalutamide is sold under the Xtandi brand name.

Obnyx 40 mg capsule is usually taken as 4 capsules (4 * 40 mg = 160 mg), once a day at the same time.

According to the company statement, 1/9 Indian males have the threat of suffering from prostate cancer, which is almost 60% of males above the age of sixty-five.

Prostate cancer remains one of the major cancers in India. The drug assists the patients by decreasing the androgen hormones in their prostate glan. Enzalutamide is used to treat prostate cancer that has spread to other parts of the body in men and who have been helped by certain medical and surgical treatments that decrease testosterone levels.

Enzalutamide is a type of hormone therapy. It is a treatment for prostate cancer that has spread to other parts of the body (advanced prostate cancer)

Approx. Rs 2,000 / BottleGet Latest Price

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REVLIMID (lenalidomide 5mg 10mg 25mg) is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). REVLIMID should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if REVLIMID is safe and effective in children.What is the most important information I should know about REVLIMID?Before you begin taking REVLIMID, you must read and agree to all of the instructions in the REVLIMID REMS® program. Before prescribing REVLIMID, your healthcare provider will explain the REVLIMID REMS program to you and have you sign the Patient-Physician Agreement Form.
REVLIMID may cause serious side effects, including:
Possible birth defects (deformed babies) or death of an unborn baby. Females who are pregnant or who plan to become pregnant must not take REVLIMID.
REVLIMID is similar to the medicine thalidomide which is known to cause severe life-threatening birth defects. REVLIMID has not been tested in pregnant females. REVLIMID has harmed unborn animals in animal testing.Females must not get pregnant:For at least 4 weeks before starting REVLIMIDWhile taking REVLIMIDDuring any breaks (interruptions) in your treatment with REVLIMIDFor at least 4 weeks after stopping REVLIMIDFemales who can become pregnant:
Must have pregnancy tests weekly for 4 weeks, then every 4 weeks if your menstrual cycle is regular, or every 2 weeks if your menstrual cycle is irregular.If you miss your period or have unusual bleeding, you will need to have a pregnancy test and receive counseling.Must agree to use 2 different forms of effective birth control at the same time, for at least 4 weeks before, while taking, during any breaks (interruptions) in your treatment, and for at least 4 weeks after stopping REVLIMID.Talk with your healthcare provider to find out about options for effective forms of birth control that you may use to prevent pregnancy before, during, and after treatment with REVLIMID.If you had unprotected sex or if you think your birth control has failed, stop taking REVLIMID immediately and call your healthcare provider right away.If you become pregnant while taking REVLIMID, stop taking it right away and call your healthcare provider. If your healthcare provider is not available, you can call Celgene Customer Care Center at 1-888-423-5436. Healthcare providers and patients should report all cases of pregnancy to:
FDA MedWatch at 1-800-FDA-1088, andCelgene Corporation, a Bristol Myers Squibb company, at 1-888-423-5436.There is a pregnancy exposure registry that monitors the outcomes of females who take REVLIMID during pregnancy, or if their male partner takes REVLIMID and they are exposed during pregnancy. You can enroll in this registry by calling Celgene Corporation, a Bristol Myers Squibb company, at the phone number listed above.
REVLIMID can pass into human semen:
Males, including those who have had a vasectomy, must always use a latex or synthetic condom during any sexual contact with a pregnant female or a female that can become pregnant while taking REVLIMID, during any breaks (interruptions) in your treatment with REVLIMID, and for up to 4 weeks after stopping REVLIMID.Do not have unprotected sexual contact with a female who is or could become pregnant. Tell your healthcare provider if you do have unprotected sexual contact with a female who is or could become pregnant.Do not donate sperm while taking REVLIMID, during any breaks (interruptions) in your treatment, and for 4 weeks after stopping REVLIMID. If a female becomes pregnant with your sperm, the baby may be exposed to REVLIMID and may be born with birth defects

Approx. Rs 1,000 / PackGet Latest Price

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Bdenza  (Enzalutamide40mg) Capsule is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Bdenza 40mg Capsule should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, hot flashes, weakness and high blood pressure is very common side effect of this medicine. Other than this, yellowing of skin, loss of appetite, shortness of breath, abdominal pain, dark urine, and skin rashes might be observed as side effects. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

In Prostate cancer Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Bdenza 40mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.
Bdenza 40 mg Capsule is used to treat castrate-resistant prostate cancer (CRPC), a stage where prostate cancer keeps growing even when there are very low levels of testosterone in the body. It is mainly used in patients whose disease has progressed on or after Docetaxel therapy. This medicine is not recommended for use in females, children, and adolescents.

Benefits Of Bdenza Capsule:
In Prostate cancerProstate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Bdenza 40mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side Effects  Of Bdenza Capsule:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about themCommon side effects of Bdenza

• Headache
• Hot flashes
• Weakness
• High blood pressure
• Fatigue

Approx. Rs 2,000 / BoxGet Latest Price

Product Details:

Capmide 40mg Capsule is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It works by blocking the effects of male hormones such as testosterone.

Capmide 40mg Capsule should be taken with or without food, preferably at a fixed time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Headache, hot flashes, weakness and high blood pressure is very common side effect of this medicine. Other than this, yellowing of skin, loss of appetite, shortness of breath, abdominal pain, dark urine, and skin rashes might be observed as side effects. Regular blood tests are required to check your blood cells along with liver function during treatment with this medicine. It makes your skin more sensitive towards sunlight, hence take extra caution while going out.

Before taking it, tell your doctor if have diabetes, seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You may be asked for regular monitoring of blood glucose level while on treatment.

Benefits Of Capmide Capsule:
In Prostate cancerProstate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Capmide 40mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side Effects Of Capmide Capsule:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Capmide:

• Headache
• Hot flashes
• Weakness
• High blood pressure
• Fatigue

How To Use Capmide Capsule:
Take this medicine in the dose and duration as advised by your doctor. Capmide 40mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Capmide Capsule works:
Capmide 40mg Capsule is an antiandrogens. It works by blocking the effect of the natural male hormones on the growth of prostate cells.

Approx. Rs 2,000 / BottleGet Latest Price

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Ibrunat (Ibrutinib 140mg)contains the Drug/Molecule called “Ibrutinib”. Ibrunat is a small molecule drug that is used to bind permanently to a protein called “Bruton’s tyrosine kinase (BTK)” which is important in B cells.

Ibrunat 140 mg Uses
Ibrunat is kind of a medicine which is prescribed for treating adult patients who has the following types of blood cancers:

• Mantle cell lymphoma
• Waldenstrom’s macroglobulinemia
• Chronic Graft Versus Host Disease
• Chronic lymphocytic leukemia and
• Marginal zone lymphoma (MZL)
• Small Lymphocytic Lymphoma

How Ibrunat Ibrutinib 140 mg Capsule Works

Ibrutinib which is the active ingredient in Ibrunat 140 mg capsules, works in a manner that it blocks the activity of a specific protein called “Bruton’s tyrosine kinase”, or BTK.

Bruton’s tyrosine kinase is a protein that is found in your B cells and it sends “signals” to the other parts of the body that help B cells to survive and multiply.

But these generic ibrunat capsules block BTK & help in killing and reducing the number of cancerous B-cells. Therefore, this stops or slows the progression of cancer.

How to Take Ibrunat Capsule
It is prescribed to take Ibrunat 140 mg once in a day at about the same time every day. The dosage and duration of treatment depends on the type of blood cancer, the age of the patient, and on how severe the condition of the patient.

Moreover, it also depends on “how the patient’s body reacts to the first dose.” The Natco Ibrunat Capsules should be taken orally with a glass of water. Please remember to not to open, crush, or chew the capsules.

Side Effects of Ibrunat Capsules
Ibrunat can cause side effects like:

• Bleeding
• Leukostasis
• Infections
• Decrease the blood cell counts
• Heart problems or Liver problems.

There are chances of occurring the new cancers in people taking Ibrunat, including skin cancer & other cancers.

The most common side effects may include:

• Pneumonia
• Upper respiratory tract infection
• Diarrhea
• Feeling very tired
• nausea
• headache
• swollen hands
• ankles or feet
• being short of breath
• dizziness
• fainting
• constipation and infected nose.

Interactions with other drugs

• Some antiplatelet drugs like “Clopidogrel”, “NSAIDs like Ibuprofen / Naproxen”, “Blood thinners like Warfarin / Dabigatran” can cause bleeding / bruising with Ibrunat capsules.
• The drug called aspirin can increase the risk of bleeding if it is used with Ibrunat Ibrutinib.
• And lastly, the azole antifungals drugs such as “Itraconazole”, “Ketoconazole” can affect the removal of Ibrunat from body.

Overdose 

• You shouldn’t take more than prescribed dose.
• The patients who have received doses higher than the recommended quantity should be carefully monitored. And most importantly, don’t ever take extra dose for the missed dose.

Precaution 
The patients taking ibrunat shouldn’t take it with grapefruit or Seville oranges. Which includes eating these fruits, drinking the juice, or taking the supplements that mat contain these fruits. It is prescribed not to take these fruits because these can increase the amount of Ibrunat in blood

Approx. Rs 2,000 / BoxGet Latest Price

Product Details:

OFEV (nintedanib 100mg 150mg) is a prescription medicine used:

• To treat people with a lung disease called idiopathic pulmonary fibrosis (IPF).
• To treat people with a chronic (long lasting) interstitial lung disease in which lung fibrosis continues to worsen (progress).
• To slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD) (also known as scleroderma-associated ILD). It is not known if OFEV is safe and effective in children.

Indications:

• Idiopathic Pulmonary  is indicated for the treatment of idiopathic pulmonary fibrosis (IPF).
• Chronic Fibrosing Interstitial Lung Diseases with A Progressive PhenotypeOFEV is indicated for the treatment of chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype [see Clinical Studies].
• Systemic Sclerosis-Associated Interstitial Lung DiseaseOFEV is indicated to slow the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).

Dosage And Administration:
Testing Prior To OFEV Administration Conduct liver function tests in all patients and a pregnancy test in females of reproductive potential prior to initiating treatment with OFEV 

Recommended Dosage

• The recommended dosage of OFEV is 150 mg twice daily administered approximately 12 hours apart.
• OFEV capsules should be taken with food 

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Retevmo (Selpercatinib 80mg) is a prescription medicine that is used to treat certain cancers caused by abnormal RET genes in adults with non-small cell lung cancer (NSCLC) that has spread, adults and children 12 years of age and older with advanced medullary thyroid cancer (MTC) or MTC that has spread who require a medicine by mouth or injection (systemic therapy), and adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working. Your healthcare provider will perform a test to make sure that Retevmo is right for you. It is not known if Retevmo is safe and effective in children younger than 12 years of age. Retevmo was approved based on the percentage of patients whose tumor size shrank or disappeared after treatment and how long the response lasted. Studies are ongoing to confirm the benefit of Retevmo for this use. Retevmo may affect both healthy cells and tumor cells, which can result in side effects, some of which can be serious. Important Facts About RETEVMO® (reh-TEHV-moh). It is also known as selpercatinib. RETEVMO is a prescription medicine that is used to treat certain cancers caused by an abnormal gene, called RET, in: adults with non-small cell lung cancer (NSCLC) that has spread. adults and children 12 years of age and older with advanced medullary thyroid cancer (MTC) or MTC that has spread, who need a medicine that can be taken by mouth or injection. adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread, who need a medicine that can be taken by mouth or injection, and who have received radioactive iodine and it did not work or is no longer working. Your doctor will perform a test to make sure that RETEVMO is right for you. It is not known if RETEVMO is safe and effective in children younger than 12 years of age. Warnings RETEVMO may cause serious side effects, including: Liver problems: Liver problems (higher levels of liver enzymes) are common with RETEVMO and may sometimes be serious. Your doctor will do blood tests before and during treatment with RETEVMO to check for liver problems. Tell your doctor right away if you get any of the following symptoms of liver problems during treatment: yellowing of your skin or the white part of your eyes (jaundice) dark, “tea-colored” urine sleepiness bleeding or bruising loss of appetite nausea or vomiting pain on the upper right side of your stomach area If you develop liver problems while taking RETEVMO, your doctor may lower your dose, stop treatment for a while, or stop treatment permanently. High blood pressure (hypertension): High blood pressure is common with RETEVMO. It may sometimes be serious. You should check your blood pressure regularly during treatment with RETEVMO. Tell your doctor if you get any of the following symptoms during treatment: confusion headaches shortness of breath dizziness chest pain Heart rhythm changes (QT prolongation) can happen. These may be serious. RETEVMO may cause very slow, very fast, or irregular heartbeats. Tell your doctor right away if you get any of the following symptoms during treatment: loss of consciousness fainting dizziness a change in the way your heart beats (heart palpitations) Bleeding problems: RETEVMO can cause bleeding, which can be serious and may lead to death. Tell your doctor if you have any signs of bleeding during treatment, including:

Approx. Rs 2,000 / VialGet Latest Price

Product Details:

VIDAZA (Azacitidine 100 Mg) is indicated for treatment of patients with the following French-American-British (FAB) Myelodysplastic Syndrome Subtypes: refractory anemia (RA) or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts (RAEB), refractory anemia with excess blasts in transformation (RAEB-T), and chronic myelomonocytic leukemia (CMMoL).

Dosage And Administration:
First Treatment Cycle The recommended starting dose for the first treatment cycle, for all patients regardless of baseline hematology laboratory values, is 75 mg/m2 subcutaneously or intravenously, daily for 7 days. Premedicate patients for nausea and vomiting. Obtain complete blood counts, liver chemistries and serum creatinine prior to the first dose. Dosage Adjustment Based On Serum Electrolytes And Renal Toxicity If unexplained reductions in serum bicarbonate levels to less than 20 mEq/L occur, reduce the dosage by 50% for the next course. Similarly, if unexplained elevations of BUN or serum creatinine occur, delay the next cycle until values return to normal or baseline and reduce the dose by 50% for the next course.

Warning And Precautions:
Use In Geriatric Patients Azacitidine and its metabolites are known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, select the dose carefully and monitor renal function.  Use In Specific Populations]. Preparation Of VIDAZ VIDAZA is a cytotoxic drug. Follow applicable special handling and disposal procedures. 1 The VIDAZA vial is single-dose and does not contain any preservatives. Discard unused portions of each vial properly [see HOW SUPPLIED]. Do not save any unused portions for later administration. Instructions For Subcutaneous Administration Reconstitute VIDAZA aseptically with 4 mL sterile water for injection. Inject the diluent slowly into the vial. Vigorously shake or roll the vial until a uniform suspension is achieved. The suspension will be cloudy. The resulting suspension will contain azacitidine 25 mg/mL. Do not filter the suspension after reconstitution. Doing so could remove the active substance. Preparation For Immediate Subcutaneous Administration For doses requiring more than 1 vial, divide the dose equally between the syringes (e.g., dose 150 mg = 6 mL, 2 syringes with 3 mL in each syringe) and inject into two separate sites. Due to retention in the vial and needle, it may not be feasible to withdraw all of the suspension from the vial. The product may be held at room temperature for up to 1 hour, but must be administered within 1 hour after reconstitution. Preparation For Delayed Subcutaneous Administration The reconstituted product may be kept in the vial or drawn into a syringe. For doses requiring more than 1 vial, divide the dose equally between the syringes (e.g., dose 150 mg = 6 mL, 2 syringes with 3 mL in each syringe) and inject into two separate sites. Due to retention in the vial and needle, it may not be feasible to withdraw all of the suspension from the vial. The product must be refrigerated immediately. When VIDAZA is reconstituted using water for injection that has not been refrigerated, the reconstituted product may be held under refrigerated conditions (2°C -8°C, 36°F -46°F) for up to 8 hours. When VIDAZA is reconstituted using refrigerated (2°C -8°C, 36°F -46°F) water for injection, the reconstituted product may be stored under refrigerated conditions (2°C -8°C, 36°F -46°F) for up to 22 hours. After removal from refrigerated conditions, the suspension may be allowed to equilibrate to room temperature for up to 30 minutes prior to administration.

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Pomalidomide is sold by Celgene Inc., in the USA, under the brand name Pomalyst. Pomalidomide is a thalidomide analogue indicated, in combination with dexamethasone, for patients with multiple myeloma (a type of blood cancer) who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on or within 60 days of completion of the last therapy. Pomalidomide is available under the name of Pomalid and is available in 3 different powers which are as follows Pomalid 1MG, 2MG, and 4MG.

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• Azacitidine For Injection is used to treat a group of blood/bone marrow disorders (myelodysplastic syndromes-MDS) in which the bone marrow does not produce enough healthy blood cells. People with MDS usually have problems such as infections, anemia, and easy bleeding/bruising. Azacitidine is a chemotherapy drug.
• It works by helping your bone marrow grow normal blood cells so you will need fewer blood transfusions. Azacitidine also kills abnormal blood cells that have grown too fast and do not work properly.

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Soranib (Sorafenib 200mg)  Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer.

Soranib Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Fatigue, nausea, loss of appetite, hair loss and diarrhea are some common side effects of this medicine. It might cause high blood pressure, so the doctor may ask you for a regular check-up of blood pressure. You must inform your doctor if you notice severe skin reaction such as skin rash, or any pain, swelling, and redness of your hands and feet.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or high blood pressure. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

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Sorafenat (Sorafenib 200mg) Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer.

Sorafenat 200mg Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Fatigue, nausea, loss of appetite, hair loss and diarrhea are some common side effects of this medicine. It might cause high blood pressure, so the doctor may ask you for a regular check-up of blood pressure. You must inform your doctor if you notice severe skin reaction such as skin rash, or any pain, swelling, and redness of your hands and feet.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or high blood pressure. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses Of Sorafenat Tablet:

• Liver cancer
• Kidney cancer
• Thyroid cancer

Benefits Of Sorafenat Tablet:
In Liver cancerLiver cancer is the cancer that develops in the cells of the liver called hepatocytes. There may be no symptoms present in the early stages of the cancer but as the disease advances to later stages symptoms such as weight loss, stomach pain, vomiting and yellowed skin. Sorafenat 200mg Tablet kills the cancer cells and prevents further growth and spread of cancer to other unaffected areas. Follow your doctor’s instructions carefully and do not drink alcohol or smoke. Alcohol intake or smoking can worsen your condition and hinder your recovery.

Side Effects Of Sorafenat Tablet:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about themCommon side effects of Sorafenat:

• Fatigue
• Nausea
• Loss of appetite
• Diarrhea
• Abdominal pain
• Hair loss
• Weight loss
• Rash
• Painful blisters on hands and feet

How To Use Sorafenat Tablet::
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sorafenat 200mg Tablet is to be taken empty stomach.

How Sorafenat Tablet Works:
Sorafenat 200mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety Advice:

• It is not known whether it is safe to consume alcohol with Sorafenat 200mg Tablet.
• Sorafenat 200mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

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Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.  Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.  Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.  Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. You must avoid driving if you experience dizziness or blurred vision during treatment. 

Uses Of Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet: 
Blood cancer (Chronic myeloid leukaemia) 

Benefits OF Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet:
In Blood cancer (Chronic myeloid leukaemia) Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side Effects Of Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet:
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Dasatinib (20 Mg, 50 Mg, 70 Mg) Abdominal pain Anemia (low number of red blood cells) Breathing problems Fatigue Fever Headache Infection Low blood platelets Musculoskeletal (bone, muscle or joint) pain Nausea Rash Vomiting.

How to use Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet: 
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet may be taken with or without food, but it is better to take it at a fixed time. 

How Dasatinib (20 Mg, 50 Mg, 70 Mg) Tablet Works: 
Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
 
Safety Advice:
It is not known whether it is safe to consume alcohol with Dasatinib (20 Mg, 50 Mg, 70 Mg) 20mg 50mg 70mg Tablet. 

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Varenicline (trade name Chantix and Champix) is a medication used for smoking cessation. Varenicline is also used for the treatment of dry eye disease.

The most common side-effects include nausea (feeling sick), insomnia (difficulty sleeping), abnormal dreams, headache and nasopharyngitis (inflammation of the nose and throat).

It is a high-affinity partial agonist for nAChRα4β2, a subtype of nicotinic acetylcholine receptor (nAChR) that leads to the release of the neurotransmitter dopamine in the nucleus accumbens (reward center of the brain) when activated, and therefore, has the capacity to reduce the feelings of craving and withdrawal caused by smoking cessation. In this respect it is similar to cytisine and different from the nicotinic antagonist bupropion and nicotine replacement therapies (NRTs) like nicotine patches and nicotine gum. It is estimated that varenicline successfully helps one of every eleven people who smoke remain abstinent from tobacco at six months.

It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2020, it was the 275th most commonly prescribed medication in the United States, with more than 1 million prescriptions

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ERLEADA (Apalutamide 60 mg) is a prescription medicine used for the treatment of prostate cancer:
that has spread to other parts of the
body and still responds to a medical or surgical treatment that lowers testosterone,OR
that has not spread to other parts of the body and no longer responds to a medical or surgical treatment that lowers testosterone.It is not known if ERLEADA® is safe and effective in females.
It is not known if ERLEADA® is safe and effective in children.
IMPORTANT SAFETY INFORMATIONBefore taking ERLEADA®, tell your healthcare provider about all your medical conditions, including if you:
have a history of heart diseasehave high blood pressurehave diabeteshave abnormal amounts of fat or cholesterol in your blood (dyslipidemia)have a history of seizures, brain injury, stroke, or brain tumorsare pregnant or plan to become pregnant. ERLEADA® can cause harm to your unborn baby and loss of pregnancy (miscarriage).have a partner who is pregnant or may become pregnant.Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 3 months after the last dose of ERLEADA®.Males should use a condom during sex with a pregnant female.Talk with your healthcare provider if you have questions about birth control.
are breastfeeding or plan to breastfeed. It is not known if ERLEADA® passes into breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ERLEADA® can interact with many other medicines.
You should not start or stop any medicine before you talk with the healthcare provider that prescribed ERLEADA®.
Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.
How should I take ERLEADA®?
Take ERLEADA® exactly as your healthcare provider tells you.Your healthcare provider may change your dose if needed.Do not stop taking your prescribed dose of ERLEADA® without talking with your healthcare provider first.Take your prescribed dose of ERLEADA® 1 time a day, at the same time each day.Take ERLEADA® with or without food.Swallow ERLEADA® tablets whole.If you miss a dose of ERLEADA®, take your normal dose as soon as possible on the same day. Return to your normal schedule on the following day. You should not take extra tablets to make up the missed dose.You should start or continue a gonadotropin-releasing hormone (GnRH) analog therapy during your treatment with ERLEADA® unless you have had a surgery to lower the amount of testosterone in your body (surgical castration).If you take too much ERLEADA®, call your healthcare provider or go to the nearest hospital emergency room.What are the possible side effects of ERLEADA®?
ERLEADA® may cause serious side effects including:
Heart Disease, Stroke, or Mini-Stroke. Bleeding in the brain or blockage of the arteries in the heart or in part of the brain have happened in some people during treatment with ERLEADA® and can lead to death. Your healthcare provider will monitor you for signs and symptoms of heart or brain problems during your treatment with ERLEADA®. Call your healthcare provider or get medical help right away if you get:chest pain or discomfort at rest or with activityshortness of breathnumbness or weakness of the face, arm, or leg, especially on one side of the bodytrouble talking or understandingtrouble seeing in one or both eyesdizziness, loss of balance or coordination, or trouble walkingFractures and Falls.

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ZOLADEX (Goserelin Acetate Implant 10.8 Mg) is a GnRH agonist. Goserelin acetate is chemically described as an acetate salt of [D-Ser(But)6,Azgly10]. Its chemical structure is pyro-Glu-His-Trp-Ser-Tyr-DSer( But)-Leu-Arg-Pro-Azgly-NH2 acetate [C59H84N18O14·(C2H4O2) where x = 1 to 2.4]. Goserelin acetate is an off-white powder with a molecular weight of 1269 Daltons (free base). It is freely soluble in glacial acetic acid. It is soluble in water, 0.1M hydrochloric acid, 0.1M sodium hydroxide, dimethylformamide and dimethyl sulfoxide. Goserelin acetate is practically insoluble in acetone, chloroform and ether. ZOLADEX is supplied as a sterile, biodegradable product containing goserelin acetate equivalent to 3.6 mg of goserelin. ZOLADEX is designed for subcutaneous injection with continuous release over a 28-day period. Goserelin acetate is dispersed in a matrix of D,L-lactic and glycolic acids copolymer (13.3-14.3 mg/dose) containing less than 2.5% acetic acid and up to 12% goserelin-related substances and presented as a sterile, white to cream colored 1-mm diameter cylinder, preloaded in a special single use syringe with a 16-gauge x 36 +/- 0.5 mm siliconized needle with protective needle sleeve (SafeSystem™ Syringe) in a sealed, light- and moisture-proof, aluminum foil laminate pouch containing a desiccant capsule. Studies of the D,L-lactic and glycolic acids copolymer have indicated that it is completely biodegradable and has no demonstrable antigenic potential. ZOLADEX is indicated for use in combination with flutamide for the management of locally confined Stage T2b-T4 (Stage B2-C) carcinoma of the prostate. Treatment with ZOLADEX and flutamide should start 8 weeks prior to initiating radiation therapy and continue during radiation therapy.

Dosage And Administration and Clinical Studies. Prostatic Carcinoma ZOLADEX is indicated in the palliative treatment of advanced carcinoma of the prostate. 
Endometriosis ZOLADEX is indicated for the management of endometriosis, including pain relief and reduction of endometriotic lesions for the duration of therapy. Experience with ZOLADEX for the management of endometriosis has been limited to women 18 years of age and older treated for 6 months.
Endometrial Thinning ZOLADEX is indicated for use as an endometrial-thinning agent prior to endometrial ablation for dysfunctional uterine bleeding. 
Advanced Breast Cancer ZOLADEX is indicated for use in the palliative treatment of advanced breast cancer in pre- and perimenopausal women. At a dose of 3.6 mg, should be administered subcutaneously every 28 days into the anterior abdominal wall below the navel line using an aseptic technique under the supervision of a physician [see Administration Technique]. While a delay of a few days is permissible, every effort should be made to adhere to the 28-day schedule. Stage B2-C Prostatic Carcinoma When ZOLADEX is given in combination with radiotherapy and flutamide for patients with Stage T2b- T4 (Stage B2-C) prostatic carcinoma, treatment should be started 8 weeks prior to initiating radiotherapy and should continue during radiation therapy. A treatment regimen using a ZOLADEX 3.6 mg depot 8 weeks before radiotherapy, followed in 28 days by the ZOLADEX 10.8 mg depot, can be administered. Alternatively, four injections of 3.6 mg depot can be administered at 28-day intervals, two depots preceding and two during radiotherapy. Prostatic Carcinoma For the management of advanced prostate cancer, ZOLADEX is intended for long-term administration unless clinically inappropriate.

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BLINCYTO (Blinatumomab 35mcg) is a prescription medicine used to treat B-cell precursor acute lymphoblastic leukemia (ALL) in patients who still have detectable traces of cancer after chemotherapy. The approval of BLINCYTO in these patients is based on a study that measured response rate and duration of response. There are ongoing studies to confirm clinical benefit. BLINCYTO (blinatumomab) is a prescription medication used to treat a certain type of acute lymphoblastic leukemia (ALL) in adults and children. ALL is a cancer of the blood and bone marrow in which a particular kind of white blood cell is replicating out of control.

Important Safety Information:
What is the most important information I should know about BLINCYTO? Call your health care provider or get emergency medical help right away if you get any of the symptoms listed below: BLINCYTO may cause serious side effects that can be severe, life-threatening, or lead to death, including: Cytokine Release Syndrome (CRS) and infusion reactions. Symptoms of CRS and infusion reactions may include: fever, tiredness or weakness, dizziness, headache, low blood pressure, nausea, vomiting, chills, face swelling, wheezing or trouble breathing, and skin rash. Neurologic problems. Symptoms of neurologic problems may include: seizures, difficulty in speaking or slurred speech, loss of consciousness, trouble sleeping, confusion and disorientation, loss of balance, headache, and difficulty with facial movements, hearing, vision, or swallowing. Your health care provider will check for these problems during treatment with BLINCYTO. Your health care provider may temporarily or completely stop your treatment with BLINCYTO if you have severe side effects.

Who should not receive BLINCYTO?
Do not receive BLINCYTO if you are allergic to blinatumomab or to any of the ingredients of BLINCYTO.

What should I avoid while receiving BLINCYTO?
Do not drive, operate heavy machinery, or do other dangerous activities while you are receiving BLINCYTO because BLINCYTO can cause neurological symptoms such as dizziness, seizures, and confusion. Before receiving BLINCYTO, tell your health care provider about all of your medical conditions, including if you or your child: have a history of neurological problems, such as seizures, confusion, trouble speaking or loss of balance have an infection have ever had an infusion reaction after receiving BLINCYTO or other medications have a history of radiation treatment to the brain, or chemotherapy treatment are scheduled to receive a vaccine. You should not receive a “live vaccine” within 2 weeks before you start treatment with BLINCYTO, during treatment, and until your immune system recovers after you receive your last cycle of BLINCYTO. If you are not sure about the type of vaccine, ask your health care provider. are pregnant or plan to become pregnant. BLINCYTO may harm your unborn baby. Tell your health care provider if you become pregnant during treatment with BLINCYTO. If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with BLINCYTO. Females who are able to become pregnant should use an effective form of birth control during treatment with BLINCYTO, and for at least 48 hours after the last dose of BLINCYTO. are breastfeeding or plan to breastfeed. It is not known if BLINCYTO passes into your breast milk. You should not breastfeed during treatment with BLINCYTO and for at least 48 hours after your last treatment. Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. BLINCYTO may cause serious side effects, including: Infections. BLINCYTO may cause life-threatening infections that may lead to death. Tell your health care provider right away in case you develop any signs or symptoms of an infection.

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Sorafekast (Sorafenib 200mg)GENERIC NAME:Sorafenib Tablets LP. 200 mg
QUALITATIVE AND QUANTITATIVE COMPOSITION:Each film-coated tablet contains: Sorafenlb tosylate IP Equivalent to Sorafeni x me Exclplents …
Colours: Feric oxide Red usr. NF. Titanium Dioxide IP.
The used are rystal Ge G Sodium, Sodium Lauryi Sulphate, Magnesium stearate, Titanium Dioxide, Macrogol/PEG and Ferric Oxide Red’.
DOSAGE FORM AND STRENGTH:-Oral (Fllm-coated tablets) and 200 mg
4. CLINICAL PARTICULARS:
4.1 Therapeutic Indication
For the treatment of patients with advanced renal cell carcinoma (RCC).
For hepatocellular Carcinoma (HCC).
For the treatment of patients with locally advanced or metastatic differentiated thyroid carcinoma
(DTC) refractory to radioactive iodine.
4.2 Posology and mathod of administration
Sorafenib treatment should be supervised by a physician experienced in the use of anticancer therapies.
The recommended dose of sorafenib in adults is 400 mg (two tablets of 200 mg) twice daily (equivalent to a total dally dose of 800 mg).
Treatment should continue as long as clinical benefit is observed or until unacceptable toxicity occurs.
When dose Is ry during the (HCC) and advanced renal cell carcinoma (RCC), the sorafenib dose snow be reduced to two tablets of 200 mg sorafenib once dally.
When dose ion is Y¥ during the of diffe i thyroid (DTC), the sorafenib dose should be reduced to 600 mg sorafenib daily in divided doses (two tablets of 200 mg and one tablet of 200 mg twelve hours apart). If additional dose reduction is necessary, sorafenib may be reduced to 400 mg sorafenib daily in divided doses (two tablets of 200 mg twelve hours apart), and If necessary further reduced to one tablet of 200mg once daily.
Paediatric population
The safety and efficacy of sorafenib in children and adolescents aged < 18 years have not yet been established. No data are available.
Elderly population
No dose adjustment Is required In the elderly (patients above 65 years of age).
Renal impairment
No dese adjustment Is required In patients with mild, moderate or severe renal Impairment. No data Is available in patients requiring dialysis. Monitoring of fluid balance and electrolytes in patients at risk of renal dysfunction is advised.
Hepatic impairment
No dose adjustment is required in patients with Child Pugh A or B (mild to moderate) hepatic impairment.
No data Is avallable on patients with Child Pugh C (severe) hepatic Impairment. may require temporary interruption or dose reduction
For oral use.
It is recommended that sorafenib should be administered without food or with a low or moderate fat meal. If the patient Intends to have a high-fat meal, sorafenib tablets should be taken at least 1 hour before or 2 hours after the meal. The tablets should be swallowed with a glass of water.

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Nexavar (Sorafenib 200mg) Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer. Nexavar 200mg Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Fatigue, nausea, loss of appetite, hair loss and diarrhea are some common side effects of this medicine. It might cause high blood pressure, so the doctor may ask you for a regular check-up of blood pressure. You must inform your doctor if you notice severe skin reaction such as skin rash, or any pain, swelling, and redness of your hands and feet. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or high blood pressure. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. USES OF NEXAVAR TABLET Liver cancer Kidney cancer Thyroid cancer BENEFITS OF NEXAVAR TABLET In Liver cancer Liver cancer is the cancer that develops in the cells of the liver called hepatocytes. There may be no symptoms present in the early stages of the cancer but as the disease advances to later stages symptoms such as weight loss, stomach pain, vomiting and yellowed skin. Nexavar 200mg Tablet kills the cancer cells and prevents further growth and spread of cancer to other unaffected areas. Follow your doctor’s instructions carefully and do not drink alcohol or smoke. Alcohol intake or smoking can worsen your condition and hinder your recovery. In Kidney cancer Nexavar 200mg Tablet is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover. In Thyroid cancer Thyroid is a butterfly-shaped gland located at the base of your neck. Your thyroid produces hormones that regulate your heart rate, blood pressure, body temperature and weight. Thyroid cancer occurs in the cells of the thyroid and it might not cause any symptoms at first. Nexavar 200mg Tablet restricts the oxygen supply of the cancer cells and stops its growth as well as further spread. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated. Show Less SIDE EFFECTS OF NEXAVAR TABLET Most side effects do not require any medical attention and disappear as your body adjusts to the medicine.

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DYRONIB (Dasatinib 70mg ) Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.
DYRONIB 70mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. 

Uses Of Sprycel Tablet:
Blood cancer (Chronic myeloid leukaemia).

Benefits Of Sprycel Tablet:
In Blood cancer (Chronic myeloid leukaemia)Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. DYRONIB 70mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Side Effects Of Sprycel Tablet:
TMost side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them Common side effects of Sprycel Abdominal pain Anemia (low number of red blood cells)Breathing problems, Fatigue, Fever,Headache, Infection, Low blood platelets, Musculoskeletal (bone, muscle or joint) pain Nausea Rash Vomiting.

How To Use Sprycel Tablet:
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. DYRONIB 70mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Sprycel Tablet Works:
DYRONIB 70mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Safety Advice:

• It is not known whether it is safe to consume alcohol with DYRONIB 70mg Tablet.
• DYRONIB 70mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. 
• DYRONIB 70mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
• DYRONIB 70mg Tablet may cause side effects which could affect your ability to drive.Take special care when driving in case you experience side effects such as dizziness and blurred vision with DYRONIB 70mg Tablet